Rodhain F
Unité d'Ecologie des Systèmes Vectoriels, Institut Pasteur, Paris.
Bull Acad Natl Med. 1992 Feb;176(2):223-36; discussion 236-9.
Because of its haemorrhagic forms often with shock syndrome, dengue fever is presently one of the most important pediatric health problems, particularly in South-east Asia. The natural reservoir of dengue is now constituted by urban human populations; travellers are the only dissemination factor of the viruses from one country to another, and all vectors are domestic species of the genus Aedes; in these mosquitoes, a vertical transmission can take place. The persistence mechanisms of dengue fever are closely related to demographic explosion, uncontrolled growth of towns and deterioration of urban environment which comes of it. The spreading mechanisms of outbreaks are related to dramatic increase of travels and the variable susceptibility of the natural Aedes populations to the viruses. All these factors appear to be directly connected with human activities; they were submitted to considerable changes since World War II and the epidemiology of the disease has been widely modified; the incidence of the disease is continuously growing year after year, building up a very worrying situation, more especially as we have no etiologic treatment nor vaccine against it.
由于登革热常伴有出血形式且往往并发休克综合征,目前它是最重要的儿科健康问题之一,在东南亚地区尤为如此。登革热的天然宿主如今是城市人群;旅行者是病毒从一个国家传播到另一个国家的唯一传播因素,且所有病媒都是伊蚊属的家蚊种类;在这些蚊子中,可发生垂直传播。登革热的持续存在机制与人口爆炸、城镇的无节制扩张以及随之而来的城市环境恶化密切相关。疫情爆发的传播机制与旅行的急剧增加以及天然伊蚊种群对病毒的易感性变化有关。所有这些因素似乎都与人类活动直接相关;自第二次世界大战以来,它们发生了重大变化,该疾病的流行病学也已被广泛改变;该病的发病率逐年持续上升,形成了非常令人担忧的局面,尤其是因为我们既没有针对它的病因治疗方法,也没有疫苗。