Esplugues Juan V
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain.
Drugs. 2005;65 Suppl 1:7-12. doi: 10.2165/00003495-200565001-00003.
Proton pump inhibitors have changed our approach to gastric acid-related diseases. They are much more potent acid inhibitors than H2-antagonists and exhibit a sophisticated mechanism of action. The present review analyses the general pharmacology of proton pump inhibitors and differentiates the specific characteristics of the various compounds that belong to this family. Special emphasis has been placed in describing the clinical implications of such differences and the potential importance for adverse effects.
质子泵抑制剂改变了我们治疗胃酸相关疾病的方法。它们是比H2拮抗剂更强效的胃酸抑制剂，并且具有复杂的作用机制。本综述分析了质子泵抑制剂的一般药理学，并区分了该家族中各种化合物的具体特征。特别强调描述了这些差异的临床意义以及对不良反应的潜在重要性。
