Williams Steven E, Brown Thomas I, Roghanian Ali, Sallenave Jean-Michel
Rayne Laboratory, Respiratory Medicine Unit, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Clin Sci (Lond). 2006 Jan;110(1):21-35. doi: 10.1042/CS20050115.
Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. We believe that elafin and SLPI are important molecules in the controlled functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed, the local production of elafin and SLPI indicate that they are ideally placed in this regard. Functionally related proteins, such as the defensins and cathelicidins, have been shown to have direct effects upon dendritic cells with potential alteration of their phenotype towards type I or II immune responses. This review addresses the multiple functions of elafin and SLPI in the inflammatory response and discusses further their roles in the development of the adaptive immune response.
弹性蛋白酶和分泌型白细胞蛋白酶抑制剂（SLPI）在正常稳态及炎症部位均发挥着多种重要作用。这些作用包括抗蛋白酶和抗菌活性，以及对脂多糖（LPS）刺激反应的调节。弹性蛋白酶和SLPI是主要在黏膜部位分泌的较大蛋白质家族的成员，并且已证实在多种病理状况下会发生调节变化。我们认为，弹性蛋白酶和SLPI是固有免疫系统正常运作中的重要分子，在该系统与适应性免疫反应的整合中可能具有更重要的意义。最近的研究兴趣集中在炎症组织对适应性免疫系统细胞募集和表型调节的影响上，实际上，弹性蛋白酶和SLPI的局部产生表明它们在这方面具有理想的定位。功能相关蛋白，如防御素和杀菌肽，已被证明对树突状细胞有直接影响，可能使其表型向I型或II型免疫反应改变。本文综述了弹性蛋白酶和SLPI在炎症反应中的多种功能，并进一步讨论了它们在适应性免疫反应发展中的作用。
