Hurley I, Hale M E, Prince V E
Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, USA.
Evol Dev. 2005 Nov-Dec;7(6):556-67. doi: 10.1111/j.1525-142X.2005.05059.x.
Duplication of genes, genomes, or morphological structures (or some combination of these) has long been thought to facilitate evolutionary change. Here we focus on studies of the teleost fishes to consider the conceptual similarities in the evolutionary potential of these three different kinds of duplication events. We review recent data that have confirmed the occurrence of a whole-genome duplication event in the ray-finned fish lineage, and discuss whether this event may have fuelled the radiation of teleost fishes. We then consider the fates of individual duplicated genes, from both a theoretical and an experimental viewpoint, focusing on our studies of teleost Hox genes and their functions in patterning the segmented hindbrain. Finally, we consider the duplication of morphological structures, once again drawing on our experimental studies of the hindbrain, which have revealed that experimentally induced duplicated neurons can produce functionally redundant neural circuits. We posit that the availability of duplicated material, independent of its nature, can lead to functional redundancy, which in turn enables evolutionary change.
基因、基因组或形态结构的重复（或这些的某种组合）长期以来一直被认为有助于进化改变。在这里，我们聚焦于硬骨鱼类的研究，以探讨这三种不同类型的重复事件在进化潜力方面的概念相似性。我们回顾了最近证实辐鳍鱼系发生了全基因组重复事件的数据，并讨论了这一事件是否可能推动了硬骨鱼类的辐射演化。然后，我们从理论和实验的角度考虑单个重复基因的命运，重点关注我们对硬骨鱼类Hox基因及其在分段后脑模式形成中的功能的研究。最后，我们考虑形态结构的重复，再次借鉴我们对后脑的实验研究，这些研究表明实验诱导的重复神经元可以产生功能冗余的神经回路。我们假定，重复物质的存在，无论其性质如何，都能导致功能冗余，进而促成进化改变。
