Shaia Norman, Heuser Richard R
The Phoenix Heart Center, Phoenix, AZ.
J Interv Cardiol. 2005 Dec;18(6):481-4. doi: 10.1111/j.1540-8183.2005.00089.x.
The development of atherosclerosis in saphenous vein grafts (SVGs) is one of the limiting factors in coronary artery bypass surgery. Approximately one half of vein conduits are significantly diseased or occluded at 10 years. A surgical revascularization strategy is often not pursued secondary to the incremental risks associated with a repeat bypass procedure. For this reason, percutaneous treatment of SVG disease is often the first option for a majority of patients. However, catheter-based treatment of SVG disease is associated with increased morbidity and mortality compared with native coronary arterial percutaneous intervention. This is often the result of distal embolization of atherothrombotic disease, leading to the phenomenon of "no-reflow." Intraprocedural pharmacological therapy has historically been the mainstay of treatment for these patients. However, more recently, the development of a mechanical embolic protection device has shown to be beneficial for the prevention of these complications. This article will review the types of embolic protection devices and the clinical studies that have proven their necessity in percutaneous SVG intervention.
大隐静脉移植物(SVG)中动脉粥样硬化的发展是冠状动脉搭桥手术的限制因素之一。大约一半的静脉导管在10年后会出现严重病变或闭塞。由于再次搭桥手术相关的风险增加,通常不会采取手术血运重建策略。因此,对于大多数患者来说,经皮治疗SVG疾病往往是首选。然而,与天然冠状动脉经皮介入治疗相比,基于导管的SVG疾病治疗与发病率和死亡率增加相关。这通常是动脉粥样硬化血栓形成疾病远端栓塞的结果,导致“无复流”现象。术中药物治疗一直是这些患者的主要治疗方法。然而,最近,机械性栓子保护装置的开发已显示出对预防这些并发症有益。本文将综述栓子保护装置的类型以及已证明其在经皮SVG介入治疗中必要性的临床研究。