Department of Surgery, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Esophagus. 2021 Jul;18(3):425-435. doi: 10.1007/s10388-021-00820-6. Epub 2021 Feb 16.
Gastroesophageal reflux disease (GERD) is a commonly diagnosed gastrointestinal disorder, with a substantial impact on the quality of life. The underlying pathophysiology of GERD is multifactorial and incompletely understood. Abnormal gastric electrical activity, measured using electrogastrography (EGG), may contribute. This study aimed to systematically review and meta-analyse the existing literature in which EGG was used in patients with GERD.
Databases were systematically searched for studies using EGG in adults with GERD. The primary outcome was the percentage of recording time in the normogastric frequency range. Secondary outcomes were dominant frequency, dominant power, power ratio and prevalence of any EGG abnormality.
In total, 591 participants (427 patients with GERD; 164 healthy controls) from 13 studies were included. GERD patients spent 17.3% (SMD - 1.18, 95%CI: - 1.84, - 0.52) and 18.7% (SMD - 1.11, 95%CI: - 1.55, - 0.68) less of the preprandial and postprandial recording time in normogastric frequency ranges, respectively, compared to healthy controls. The dominant frequency, dominant power and power ratio were not significantly different to healthy controls in the preprandial and postprandial periods. The pooled prevalence of any EGG abnormality was significantly greater in patients with GERD than in healthy controls [46% (95%CI: 39-64%) vs. 10% (95%CI: 4-23%); p < 0.0001]. Correlations between GERD symptoms and EGG recordings were inconsistently studied. EGG techniques were heterogeneous.
Consistent abnormalities in gastric slow-wave activity, as measured by EGG, were identified in adults with GERD. Further investigation into these abnormalities using novel emerging electrophysiology techniques is desirable, to better define their contribution toward GERD pathophysiology.
胃食管反流病（GERD）是一种常见的胃肠道疾病，对生活质量有重大影响。GERD 的潜在病理生理学是多因素的，目前尚未完全了解。使用胃电图（EGG）测量的异常胃电活动可能与此有关。本研究旨在系统回顾和荟萃分析目前使用 EGG 检测 GERD 患者的文献。
系统检索使用 EGG 检测成人 GERD 的研究。主要结果是正常胃电频率范围内的记录时间百分比。次要结果是主导频率、主导功率、功率比和任何 EGG 异常的发生率。
共纳入 13 项研究的 591 名参与者（427 名 GERD 患者；164 名健康对照者）。与健康对照组相比，GERD 患者的餐前和餐后记录时间中，分别有 17.3%（SMD-1.18，95%CI：-1.84，-0.52）和 18.7%（SMD-1.11，95%CI：-1.55，-0.68）处于正常胃电频率范围。餐前和餐后，主导频率、主导功率和功率比与健康对照组无显著差异。GERD 患者任何 EGG 异常的总体发生率明显高于健康对照组[46%（95%CI：39-64%）比 10%（95%CI：4-23%）；p<0.0001]。GERD 症状与 EGG 记录之间的相关性研究结果不一致。EGG 技术存在异质性。
在 GERD 成人中，通过 EGG 测量到胃慢波活动存在一致的异常。使用新出现的电生理学技术进一步研究这些异常，有助于更好地确定其对 GERD 病理生理学的贡献。
