Proebstle Thomas M, Moehler Thomas, Gül Doendue, Herdemann Sylvia
Department of Dermatology, University of Heidelberg, Germany.
Dermatol Surg. 2005 Dec;31(12):1678-83; discussion 1683-4. doi: 10.2310/6350.2005.31308.
Limited data are available about treatment-related side effects with respect to laser wavelength in endovenous laser treatment (ELT) of the great saphenous vein (GSV).
To compare the results and side effects of a 940 nm diode and a 1,320 nm neodymium:yttium-aluminum-garnet (Nd:YAG) laser.
Three patient cohorts (A, B, and C) received ELT of the GSV using a 940 nm diode laser at 15 W (group A) or 30 W (group B) or using a 1,320 nm laser at 8 W (group C). In all cases, energy was administered continuously with constant pullback of the laser fiber under perivenous tumescent local anesthesia.
The GSVs of group A (n = 113), group B (n = 136), and group C (n = 33) received ELT. An average linear endovenous energy density of 24, 63, and 62 J/cm and an average endovenous fluence equivalent of 12, 30, and 33 J/cm2 were administered to the vein. Occlusion rates were 95% (group A), 100% (group B), and 100% (group C) at day 1 after ELT and 90.3% (group A), 100% (group B), and 97% (group C) at 3 months after ELT. With the 1,320 nm laser ELT (group C), treatment-related pain (50%) and the need for analgesics (36%) were significantly reduced (p < .005) in comparison with treatment-related pain (81%) and the need for analgesics (67%) after the 30 W 940 nm laser ELT (group B). Ecchymosis was also significantly reduced (p < .05) in group C (1,320 nm) compared with group B (30 W, 940 nm).
ELT of the GSV using a 1,320 nm Nd:YAG laser causes fewer side effects compared with 940 nm diode laser ELT.
关于大隐静脉腔内激光治疗（ELT）中激光波长与治疗相关副作用的可用数据有限。
比较940nm二极管激光和1320nm钕：钇铝石榴石（Nd：YAG）激光的治疗结果和副作用。
三个患者队列（A、B和C）接受了大隐静脉的腔内激光治疗，A组使用15W的940nm二极管激光，B组使用30W的940nm二极管激光，C组使用8W的1320nm激光。在所有病例中，在静脉周围肿胀局部麻醉下，随着激光光纤的持续回撤连续给予能量。
A组（n = 113）、B组（n = 136）和C组（n = 33）的大隐静脉接受了腔内激光治疗。静脉接受的平均线性腔内能量密度分别为24、63和62 J/cm，平均腔内能量通量当量分别为12、30和33 J/cm²。腔内激光治疗后第1天的闭塞率分别为95%（A组）、100%（B组）和100%（C组），腔内激光治疗后3个月的闭塞率分别为90.3%（A组）、100%（B组）和97%（C组）。与30W 940nm激光腔内激光治疗（B组）后的治疗相关疼痛（81%）和镇痛需求（67%）相比，1320nm激光腔内激光治疗（C组）的治疗相关疼痛（50%）和镇痛需求（36%）显著降低（p < .005）。与B组（30W，940nm）相比，C组（1320nm）的瘀斑也显著减少（p < .05）。
与940nm二极管激光腔内激光治疗相比，使用1320nm Nd：YAG激光进行大隐静脉腔内激光治疗产生的副作用更少。
