Kálmán János, Juhász Anna, Bogáts Gábor, Babik Barna, Rimanóczy Agnes, Janka Zoltán, Penke Botond, Palotás András
Department of Psychiatry, Albert Szent-Györgyi Medical and Pharmaceutical Center, Faculty of Medicine, University of Szeged, H-6721 Szeged, Semmelweis u. 6, Hungary.
Neurochem Int. 2006 Feb;48(3):177-80. doi: 10.1016/j.neuint.2005.10.007. Epub 2005 Dec 5.
Recovery from cardiac surgery is marred for many patients by the development of neurological, psychological or cognitive dysfunction. An uncontrolled inflammatory reaction, in response to surgical stress, may be responsible. To confirm this hypothesis, the present study evaluated changes in the levels of cytokines in cerebrospinal fluid after coronary artery bypass grafting. One week post-operatively, the concentration of the pro-inflammatory cytokine interleukin-6 markedly increased; 6 months after surgery, however, its level normalized with an increased concentration of the anti-inflammatory interleukin-4. This suggests that a regulated immune response may participate in developing adverse neurologic events and complications following cardiac interventions, and cytokines in the cerebrospinal fluid may serve as specific biomarkers and predictors of developing cognitive decline after coronary surgery.
许多患者心脏手术后的恢复因神经、心理或认知功能障碍的出现而受到影响。对手术应激产生的不受控制的炎症反应可能是原因所在。为证实这一假设，本研究评估了冠状动脉搭桥术后脑脊液中细胞因子水平的变化。术后一周，促炎细胞因子白细胞介素-6的浓度显著升高；然而，术后6个月，其水平恢复正常，同时抗炎性白细胞介素-4的浓度增加。这表明，调节性免疫反应可能参与心脏介入术后不良神经事件和并发症的发生，脑脊液中的细胞因子可能作为冠状动脉手术后认知功能下降的特定生物标志物和预测指标。
