Lam Jamie C M, Lam Bing, Lam Chi-Leung, Fong Daniel, Wang Julie K L, Tse Hung-Fat, Lam Karen S L, Ip Mary S M
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, SAR, China.
Respir Med. 2006 Jun;100(6):980-7. doi: 10.1016/j.rmed.2005.10.003. Epub 2005 Dec 5.
To investigate the relationship between obstructive sleep apnea (OSA) and the metabolic syndrome, an established cardiovascular risk factor, in middle-aged Chinese subjects.
A prospective cross-sectional study from community-dwelling volunteers.
Subjects of either sex between 30 and 60 years old were recruited from the staff in public institutions or visitors to community centers in Hong Kong.
Demographic and anthropomentric indices, blood pressure and metabolic profile (fasting blood glucose, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and triglycerides) were measured. Overnight polysomnographic studies were conducted. Presence of obstructive sleep apnea (OSA) was defined as apnea-hypopnea index (AHI)5. Metabolic syndrome was defined by the criteria of the National Cholesterol Education Panel, but using Asian cut-off values for abdominal obesity.
A total of 255 subjects (150 men, 105 women) were studied. Subjects with OSA had five-fold risk of having metabolic syndrome. OSA was associated with the metabolic syndrome or its components, including waist circumference, diastolic blood pressure and fasting glucose, after adjusting for confounding variables. The independent determinants of OSA were age, gender, body mass index (BMI) and the metabolic syndrome.
Among community-based middle-aged Chinese subjects, the metabolic syndrome was independent predictor of OSA.
研究中年中国人群中阻塞性睡眠呼吸暂停（OSA）与已确定的心血管危险因素代谢综合征之间的关系。
一项针对社区志愿者的前瞻性横断面研究。
从香港公共机构工作人员或社区中心访客中招募年龄在30至60岁之间的男女受试者。
测量人口统计学和人体测量学指标、血压和代谢指标（空腹血糖、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯）。进行整夜多导睡眠图研究。阻塞性睡眠呼吸暂停（OSA）的存在定义为呼吸暂停低通气指数（AHI）≥5。代谢综合征根据美国国家胆固醇教育计划的标准定义，但采用亚洲腹部肥胖切点值。
共研究了255名受试者（150名男性，105名女性）。患有OSA的受试者患代谢综合征的风险是常人的五倍。在调整混杂变量后，OSA与代谢综合征或其组成部分有关，包括腰围、舒张压和空腹血糖。OSA的独立决定因素是年龄、性别、体重指数（BMI）和代谢综合征。
在以社区为基础的中年中国人群中，代谢综合征是OSA的独立预测因素。
