Bajpai Jyoti, Pradhan Akshyaya, Bajaj Darshan, Verma Ajay Kumar, Kant Surya, Pandey Akhilesh Kumar, Sethi Rishi, Dubey Abhishek
Department of Respiratory Medicine, King George's Medical University Lucknow, U.P, India.
Department of Cardiology, King George's Medical University Lucknow, India.
Am J Cardiovasc Dis. 2023 Feb 15;13(1):1-9. eCollection 2023.
Background Obstructive sleep apnea (OSA) is associated with many diseases, but evidence indicating that OSA is a risk factor for dyslipidemia is lacking. Aim This cross-sectional study investigated the prevalence of lipid abnormalities in patients with OSA and its association with OSA severity.
In this cross-sectional study, 102 patients with suspected OSA underwent standard polysomnography. All patients with an apnea-hypopnea index (AHI) of ≥5 with symptoms were diagnosed as having OSA. A fasting blood sample was collected from all patients. Blood levels of triglycerides (TGs), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), and low-density lipoprotein cholesterol (LDL) were measured. The relationship between the AHI and lipid profiles was analyzed, and linear regression analysis was performed to evaluate the effect of dyslipidemia on OSA.
The patients with OSA had a significantly higher TG level and a significantly lower HDL level than did those without OSA. The lipid abnormalities increased with OSA severity. The mean serum TG level was higher in the severe OSA group (175±46.5 vs. 153±42.45, mg/dl P = 0.048), and the mean serum HDL level was lower in the severe OSA group (38.43 ± 5.19 vs. 45.73 ± 4.98, mg/dl P = 0.004). Serum TG, cholesterol, and LDL levels were correlated with a BMI of <30 and a BMI of >30 in the OSA group. Linear regression analysis indicated that only age (β = 0.301, P = 0.000), BMI (β = 0.455, P = 0.000), serum HDL level (β = -0.297, P = 0.012), and serum LDL level (β = 0.429, P = 0.001) were the independent predictors of OSA.
OSA and obesity are potential risk factors for dyslipidemia. The diagnosis of hyperlipidemia was linked to OSA, and the association was more significant with OSA severity. Hyperlipidemia was well recognized in patients with OSA. LDL and HDL are the independent predictors of OSA.
背景 阻塞性睡眠呼吸暂停（OSA）与多种疾病相关，但缺乏证据表明OSA是血脂异常的危险因素。目的 这项横断面研究调查了OSA患者脂质异常的患病率及其与OSA严重程度的关联。
在这项横断面研究中，102例疑似OSA患者接受了标准多导睡眠图检查。所有呼吸暂停低通气指数（AHI）≥5且有症状的患者被诊断为患有OSA。采集所有患者的空腹血样。测量血甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL）和低密度脂蛋白胆固醇（LDL）水平。分析AHI与血脂谱之间的关系，并进行线性回归分析以评估血脂异常对OSA的影响。
与无OSA的患者相比，OSA患者的TG水平显著更高，HDL水平显著更低。脂质异常随OSA严重程度增加而增加。重度OSA组的平均血清TG水平更高（175±46.5对153±42.45，mg/dl，P = 0.048），重度OSA组的平均血清HDL水平更低（38.43±5.19对45.73±4.98，mg/dl，P = 小0.004）。OSA组中血清TG、胆固醇和LDL水平与BMI<30和BMI>30相关。线性回归分析表明，只有年龄（β = 0.301，P = 0.000）、BMI（β = 0.455，P = 0.000）、血清HDL水平（β = -0.297，P = 0.012）和血清LDL水平（β = 0.429，P = 0.001）是OSA的独立预测因素。
OSA和肥胖是血脂异常的潜在危险因素。高脂血症的诊断与OSA相关，且这种关联在OSA严重程度更高时更为显著。OSA患者中高脂血症得到了充分认识。LDL和HDL是OSA的独立预测因素。
