有过早产双胞胎分娩经历的女性，在随后的单胎妊娠中早产风险会更高吗？
Are women who have had a preterm twin delivery at greater risk of preterm birth in a subsequent singleton pregnancy?
作者信息
Facco Francesca L, Nash Kate, Grobman William A
机构信息
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
出版信息
Am J Obstet Gynecol. 2007 Sep;197(3):253.e1-3. doi: 10.1016/j.ajog.2007.06.049.
OBJECTIVE
The purpose of this study was to determine whether preterm birth of twins is associated with an increased risk of preterm birth in a subsequent singleton pregnancy.
STUDY DESIGN
All patients who delivered a twin gestation and a subsequent singleton pregnancy at Northwestern Memorial Hospital during a 10-year period were identified. We used a cohort study design, comparing the outcomes of the singleton pregnancies in women with preterm twin deliveries to those pregnancies with term twin deliveries.
RESULTS
One hundred sixty-seven women delivered twins followed by a singleton pregnancy. Women whose twin delivery was preterm (n = 99) were more likely than those who had delivered a term twin pregnancy (n = 68) to deliver a subsequent preterm singleton pregnancy (13.1% vs 2.9%; odds ratio, 5.0; 95% CI, 1.1, 22.9).
CONCLUSION
Preterm birth of twins is associated with an increased risk of preterm delivery in a subsequent singleton pregnancy.
目的
本研究旨在确定双胎早产是否与随后单胎妊娠的早产风险增加相关。
研究设计
确定了在10年期间于西北纪念医院分娩双胎妊娠及随后单胎妊娠的所有患者。我们采用队列研究设计，比较早产双胎分娩女性的单胎妊娠结局与足月双胎分娩女性的单胎妊娠结局。
结果
167名女性分娩双胎后又有单胎妊娠。双胎早产的女性（n = 99）比足月双胎妊娠的女性（n = 68）更有可能分娩随后的早产单胎妊娠（13.1% 对2.9%；优势比，5.0；95%可信区间，1.1，22.9）。
结论
双胎早产与随后单胎妊娠的早产风险增加相关。
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