Born Willi K, Reardon Christopher L, O'Brien Rebecca L
Department of Immunology, at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
Curr Opin Immunol. 2006 Feb;18(1):31-8. doi: 10.1016/j.coi.2005.11.007. Epub 2005 Dec 6.
Many researchers believe that gammadelta T lymphocytes belong somewhere 'in-between' the innate and adaptive immune systems. Recent studies strongly emphasize the innate features and functions of these cells, including the use of germline elements of the T cell receptor for ligand recognition, segregation into functionally specialized cell populations in correlation with T cell receptor variable gene or protein expression, interactions with cells of the innate system at many levels and, the latest addition, the ability to present antigen. Thus, at present, much evidence suggests that gammadelta T cells function in an innate manner, although they are arguably the most complex and advanced cellular representatives of the innate immune system.
许多研究人员认为，γδ T淋巴细胞介于先天性免疫系统和适应性免疫系统之间。最近的研究强烈强调了这些细胞的先天性特征和功能，包括利用T细胞受体的种系元件进行配体识别、根据T细胞受体可变基因或蛋白质表达分离为功能专门化的细胞群体、在多个层面与先天性免疫系统的细胞相互作用，以及最新发现的抗原呈递能力。因此，目前有很多证据表明γδ T细胞以先天性方式发挥作用，尽管它们可以说是先天性免疫系统中最复杂和最先进的细胞代表。
