Takamatsu H-H, Denyer M S, Stirling C, Cox S, Aggarwal N, Dash P, Wileman T E, Barnett P V
Immunology Division, Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, UK.
Vet Immunol Immunopathol. 2006 Jul 15;112(1-2):49-61. doi: 10.1016/j.vetimm.2006.03.011. Epub 2006 May 22.
gammadelta T cells recognise different types of antigen in alternative ways to alphabeta T cells, and thus appear to play a complementary role in the immune response. However, unlike alphabeta T cells, the role or function of gammadelta T cells is still unclear. As pigs possess a high proportion of circulating gammadelta T cells, they are suitable large animal model to study gammadelta T cell functions. This as yet has not been fully exploited, leaving porcine gammadelta T cell biology and its role in immunity in its infancy. Foot-and-mouth disease (FMD) high potency "emergency" vaccines are able to induce early protection from challenge and it has been suggested that, in part, there is some involvement of innate immune responses. The antigen component of the vaccine is able to stimulate purified naive pig gammadelta T cells and induce the mRNA of various cytokines and chemokines. This observation suggests that gammadelta T cells probably contribute to the early phase of the immune responses to FMD vaccination, and perhaps infection. A subset of these circulating gammadelta T cells display a phenotype similar to professional antigen presenting cells and are able to take up and present soluble antigen to CD4(+) T cells in a direct cell-cell interaction via MHC class II. This direct interaction between gammadelta T cells and CD4(+) T cells is likely to have a significant influence on the out come of the adaptive immune response.
γδ T细胞以与αβ T细胞不同的方式识别不同类型的抗原，因此似乎在免疫反应中发挥着互补作用。然而，与αβ T细胞不同，γδ T细胞的作用或功能仍不清楚。由于猪体内循环γδ T细胞的比例很高，它们是研究γδ T细胞功能的合适的大型动物模型。但这一点尚未得到充分利用，使得猪γδ T细胞生物学及其在免疫中的作用仍处于起步阶段。口蹄疫（FMD）高效“紧急”疫苗能够诱导早期保护以抵御攻击，并且有人提出，这在一定程度上涉及先天免疫反应。疫苗的抗原成分能够刺激纯化的猪幼稚γδ T细胞，并诱导各种细胞因子和趋化因子的mRNA表达。这一观察结果表明，γδ T细胞可能有助于对口蹄疫疫苗接种以及可能的感染产生免疫反应的早期阶段。这些循环γδ T细胞的一个亚群表现出与专业抗原呈递细胞相似的表型，并且能够通过MHC II类分子在直接的细胞间相互作用中摄取可溶性抗原并将其呈递给CD4(+) T细胞。γδ T细胞与CD4(+) T细胞之间的这种直接相互作用可能对适应性免疫反应的结果产生重大影响。
