Craig Timothy J, Hanks Christopher D, Fisher Laura H
Allergy, Asthma and Immunology Section, Penn State University, Hershey Medical Center, Hershey, PA 17033, USA.
J Allergy Clin Immunol. 2005 Dec;116(6):1264-6. doi: 10.1016/j.jaci.2005.10.009.
Therapy for rhinitis improves sleep quality and symptoms of daytime sleepiness. This improvement with therapy may be secondary to anti-inflammatory effects, leading to a reduction of inflammatory mediators, or to a mechanical reduction of congestion directly leading to improvement in sleep disturbance. We combined our data from 3 placebo-controlled studies of intranasal corticosteroids in patients with perennial rhinitis to determine whether a correlation between the reduction of congestion and improved sleep and daytime somnolence existed. The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients. The data demonstrated a correlation between a reduction in nasal congestion and an improvement of sleep (P < .01) and daytime somnolence (P = .01). Thus, topical intranasal corticosteroids should be used to decrease nasal congestion and to improve sleep and daytime somnolence in patients manifesting these symptoms.
鼻炎治疗可改善睡眠质量和日间嗜睡症状。治疗带来的这种改善可能继发于抗炎作用，导致炎症介质减少，或者继发于直接改善睡眠障碍的机械性减轻充血作用。我们汇总了3项关于常年性鼻炎患者鼻用糖皮质激素的安慰剂对照研究的数据，以确定充血减轻与睡眠改善及日间嗜睡之间是否存在相关性。布地奈德、氟尼缩松和氟替卡松的汇总数据显示，治疗患者的鼻充血、睡眠问题和嗜睡症状均显著减轻。数据表明，鼻充血减轻与睡眠改善（P <.01）和日间嗜睡改善（P =.01）之间存在相关性。因此，对于出现这些症状的患者，应使用鼻用糖皮质激素局部用药来减轻鼻充血，并改善睡眠和日间嗜睡症状。
