O'Donnell E Paul, Zerbe Laura K, Dwyer-Nield Lori D, Kisley Lori R, Malkinson Alvin M
Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Box C238, 4200 East Ninth Avenue, Denver, CO 80262, USA.
Cancer Lett. 2006 Sep 28;241(2):197-202. doi: 10.1016/j.canlet.2005.10.012. Epub 2005 Dec 7.
Inbred mice vary in their susceptibility to develop macroscopic, chemically-induced, pulmonary neoplasias. It is not known, however, whether microscopic lesions appear in resistant strains but do not grow or if no early lesions arise at all. We show herein that resistant C57BL/6J (B6) and intermediately resistant BALB/cByJ (BALB) mice form very few urethane-induced early microadenomas (i.e. adenomas larger than hyperplasic foci, but detectable only by light microscopy). Additionally, while all urethane-induced microadenomas in sensitive A/J mice gave rise to adenomas, most microscopic tumors induced in BALB mice by 2-stage, 3-methylcholanthrene/butylated hydroxytoluene carcinogenesis spontaneously regressed. The formation of microscopic lesions is thus genetically dependent, but whether they continue to grow or regress depends on how they were induced.
近交系小鼠对化学诱导的宏观肺部肿瘤的易感性各不相同。然而，尚不清楚在抗性品系中是否会出现微观病变但不生长，或者是否根本不会出现早期病变。我们在此表明，抗性C57BL/6J（B6）和中度抗性BALB/cByJ（BALB）小鼠形成的氨基甲酸乙酯诱导的早期微腺瘤非常少（即腺瘤大于增生灶，但仅通过光学显微镜可检测到）。此外，虽然敏感的A/J小鼠中所有氨基甲酸乙酯诱导的微腺瘤都发展成了腺瘤，但在BALB小鼠中，由二阶段3-甲基胆蒽/丁基化羟基甲苯致癌作用诱导的大多数微观肿瘤会自发消退。因此，微观病变的形成是由基因决定的，但它们是继续生长还是消退取决于诱导方式。
