Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells.
作者信息
Nagami Hideaki, Nakano Koji, Ichihara Hideaki, Matsumoto Yoko, Ueoka Ryuichi
机构信息
Graduate Course of Applied Chemistry, Sojo University, Ikeda, Kumamoto 860-0082, Japan.
出版信息
Bioorg Med Chem Lett. 2006 Feb 15;16(4):782-5. doi: 10.1016/j.bmcl.2005.11.034. Epub 2005 Dec 6.
PMID:16337792
Abstract
High inhibitory effects of hybrid liposomes (HL) themselves composed of DMPC/10 mol% C12(EO)23 on the growth of HL-60 cells were obtained without any drug. Induction of apoptosis was obtained by the HL of DMPC/10 mol% C12(EO)23. On the other hand, necrosis was observed for the HL of DLPC/10 mol% C12(EO)23. In the case of DPPC/10 mol% C12(EO)23, neither apoptosis nor necrosis was observed.
摘要
Zotero 插件