Mason Jacqueline M, Morrison Debra J, Basson M Albert, Licht Jonathan D
Mount Sinai School of Medicine, Department of Medicine, Division of Hematology and Oncology, Box 1079, One Gustave L. Levy Place, New York, NY 10029, USA.
Trends Cell Biol. 2006 Jan;16(1):45-54. doi: 10.1016/j.tcb.2005.11.004. Epub 2005 Dec 7.
Receptor tyrosine kinases (RTKs) control a wide variety of processes in multicellular organisms, including proliferation, differentiation, migration and survival. Their activity is tightly controlled through the coordinated action of both positive and negative regulators that function at multiple levels of the signal transduction cascade, and at different time points within the growth-factor-induced response. When this process goes awry, the outcome can be developmental defects and malignancy. Sprouty (Spry) proteins represent a major class of ligand-inducible inhibitors of RTK-dependent signaling pathways. New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of the Spry proteins in regulation of the RTK-induced response.
受体酪氨酸激酶（RTK）控制多细胞生物中的多种过程，包括增殖、分化、迁移和存活。它们的活性通过正负调节因子的协同作用受到严格控制，这些调节因子在信号转导级联的多个层面以及生长因子诱导反应的不同时间点发挥作用。当这个过程出现差错时，结果可能是发育缺陷和恶性肿瘤。Sprouty（Spry）蛋白是RTK依赖性信号通路的一类主要的配体诱导抑制剂。新的生化和遗传学证据表明Spry基因在发育中的特定作用以及Spry蛋白在调节RTK诱导反应中的多种作用模式。
