Espeli Marion, Rossi Benjamin, Mancini Stéphane J C, Roche Philippe, Gauthier Laurent, Schiff Claudine
Centre d'Immunologie de Marseille-Luminy (CIML), CNRS-INSERM-University Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.
Semin Immunol. 2006 Feb;18(1):56-66. doi: 10.1016/j.smim.2005.11.002. Epub 2005 Dec 7.
B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition, the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed on the bases of the differences reported for pre-BCR and IL7 dependencies in the two species.
骨髓中的B细胞发育是一个高度受调控的过程，功能性前B细胞受体（pre-BCR）的表达是人和小鼠共有的一个关键检查点。在这篇综述中，我们讨论了导致前B细胞分化和增殖的两个物种之间前BCR的异同。此外，考虑到最近关于硫酸乙酰肝素和半乳糖凝集素1作为基质细胞衍生的前BCR配体的报道，对触发前BCR激活的机制进行了综述。最后，根据报道的两个物种在前BCR和IL7依赖性方面的差异，提出了配体诱导的前BCR激活模型。
