Monnaie D, Virden R, Frère J M
Laboratoire d'enzymologie, Université de Liège, Belgium.
FEBS Lett. 1992 Jul 20;306(2-3):108-12. doi: 10.1016/0014-5793(92)80979-q.
The individual rate constants for acylation and deacylation (k2 and k3, respectively) of the class C beta-lactamase of Enterobacter cloacae 908R by ampicillin and carbenicillin have been determined. For several other beta-lactams, the value of k2 was too high to be determined and the k2/k3 ratio could be larger than 10,000. Branched pathways were also shown to occur with several penicillins and cephalosporins.
已测定氨苄西林和羧苄西林对阴沟肠杆菌908R的C类β-内酰胺酶进行酰化和去酰化反应的个体速率常数（分别为k2和k3）。对于其他几种β-内酰胺类药物，k2的值过高无法测定，且k2/k3比值可能大于10,000。还发现几种青霉素和头孢菌素存在分支途径。
