Lewis M P, Colbert A, Erlen J, Meyers M
Department of Nursing and Allied Health, State University of New York at Delhi, Delhi, NY 13753, USA.
AIDS Care. 2006 Feb;18(2):140-8. doi: 10.1080/09540120500161835.
This qualitative study examined the medication-taking behaviors and attitudes of participants determined to be 100% adherers to antiretroviral therapy from a NIH-funded study testing a 12-week telephone adherence intervention. Using open-ended questions, interviewers collected data on a sample of 13 informants, whose medication adherence to a randomly selected antiretroviral medication was 100%, based on a 30-day data collection using electronic event monitoring (EEM). The analysis revealed 'successful medication management' as the core category or main theme. The participants achieved success with medication adherence through managing specific areas (regimen, self and environment). By adopting realistic expectations and pragmatic attitudes, adherence is fostered when medication taking is a priority, when patients believe in the efficacy of their medications and when there is a strong patient/provider relationship. Future research is needed to develop tailored interventions using strategies identified by this population. Further in-depth examination of medication-taking behaviors in 100% adherers may be useful in developing individualized programs to maximize adherence to antiretroviral therapy in the clinical setting.
这项定性研究调查了来自一项由美国国立卫生研究院资助、测试为期12周电话依从性干预措施的研究中，被确定为抗逆转录病毒疗法100%依从者的参与者的服药行为和态度。访谈者通过开放式问题，收集了13名受访者的数据样本，基于使用电子事件监测（EEM）进行的30天数据收集，这些受访者对随机选择的抗逆转录病毒药物的服药依从率为100%。分析揭示了“成功的药物管理”作为核心类别或主要主题。参与者通过管理特定领域（治疗方案、自我和环境）实现了服药依从性的成功。通过采取现实的期望和务实的态度，当服药成为优先事项、患者相信药物的疗效以及存在牢固的患者/提供者关系时，依从性就会得到促进。需要开展未来研究，以使用该群体确定的策略制定量身定制的干预措施。对100%依从者的服药行为进行进一步深入研究，可能有助于制定个性化方案，以在临床环境中最大限度地提高对抗逆转录病毒疗法的依从性。
