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Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots.全球精症主要是由于 DPY19L2 通过涉及两个重组热点的非等位同源重组缺失所致。
Hum Mol Genet. 2012 Aug 15;21(16):3695-702. doi: 10.1093/hmg/dds200. Epub 2012 May 31.
2
Medication adherence: helping patients take their medicines as directed.药物依从性：帮助患者按医嘱服药。
Public Health Rep. 2012 Jan-Feb;127(1):2-3. doi: 10.1177/003335491212700102.
3
Motivation to physical activity among adults with high risk of type 2 diabetes who participated in the Oulu substudy of the Finnish Diabetes Prevention Study.2 型糖尿病高危成年人参与芬兰糖尿病预防研究奥卢分研究的体力活动动机。
Health Soc Care Community. 2011 Jan;19(1):15-22. doi: 10.1111/j.1365-2524.2010.00942.x. Epub 2010 Sep 9.
4
Characteristics of different phenotypes of polycystic ovary syndrome based on the Rotterdam criteria in a large-scale Chinese population.基于 Rotterdam 标准的中国大样本人群中多囊卵巢综合征不同表型的特征。
BJOG. 2009 Nov;116(12):1633-9. doi: 10.1111/j.1471-0528.2009.02347.x. Epub 2009 Sep 14.
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Repertoires of lifestyle change and self-responsibility among participants in an intervention to prevent type 2 diabetes.一项预防2型糖尿病干预措施参与者的生活方式改变和自我责任清单
Scand J Caring Sci. 2008 Sep;22(3):455-62. doi: 10.1111/j.1471-6712.2007.00551.x.
6
Educational inequalities in self-reported health in a general Iranian population.伊朗普通人群自我报告健康状况中的教育不平等现象。
BMC Res Notes. 2008 Jul 21;1:50. doi: 10.1186/1756-0500-1-50.
7
Participants' perspective on maintaining behaviour change: a qualitative study within the European Diabetes Prevention Study.参与者对维持行为改变的看法：欧洲糖尿病预防研究中的一项定性研究。
BMC Public Health. 2008 Jul 10;8:235. doi: 10.1186/1471-2458-8-235.
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Successful pregnancy and childbirth after intracytoplasmic sperm injection with calcium ionophore oocyte activation in a globozoospermic patient.一名圆头精子症患者经钙离子载体卵母细胞激活的卵胞浆内单精子注射后成功妊娠并分娩。
Fertil Steril. 2008 Oct;90(4):1202.e1-5. doi: 10.1016/j.fertnstert.2007.11.056. Epub 2008 Mar 21.
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Perceived barriers and effective strategies to diabetes self-management.糖尿病自我管理中感知到的障碍及有效策略。
J Adv Nurs. 2006 Apr;54(2):151-8. doi: 10.1111/j.1365-2648.2006.03799.x.
10
Is there a relationship between sperm chromosome abnormalities and sperm morphology?精子染色体异常与精子形态之间存在关联吗？
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多囊卵巢综合征女性治疗依从性的促进因素和抑制因素：一项定性研究。

Facilitating and inhibiting factors related to treatment adherence in women with polycystic ovary syndrome: A qualitative study.

作者信息

Bazarganipour Fatemeh, Taghavi Seyed Abdolvahab, Allan Helen, Hosseini Nazafarin

机构信息

Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

Int J Reprod Biomed. 2017 Sep;15(9):553-560.

PMID:29662963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5894471/
Abstract

BACKGROUND

Adherence issues in polycystic ovary syndrome (PCOS) patients have not been examined thoroughly. Patients report prolonged periods of treatment and side effects of the drug as the most common reason for withdrawal from treatment. To improve the effective management of PCOS patients, it is fundamental to understand facilitating and inhibiting factors to treatment adherence.

OBJECTIVE

To explore facilitating/inhibiting factors related to treatment adherence among PCOS patients.

MATERIALS AND METHODS

This was a qualitative study with a purposive sample of women with confirmed diagnosis of PCOS. The data were collected via 20 in-depth semi-structured interviews with women aged between 21-34 yr. A qualitative content analysis was used to analyze the data.

RESULTS

Five themes were identified which described different types of facilitating/ inhibiting factors to treatment adherence. Inhibiting factors included financial issues, patient-related, disease-related, and health care provider-related factors; while social factors were found to be both facilitating and inhibiting.

CONCLUSION

The findings suggest that successful adherence to PCOS treatment is highly dependent on patients recognizing and adapting to financial, social, and health care related inhibiting factors. It is also crucial for clinicians and policy makers to recognize these key inhibiting factors in order to improve treatment outcomes

摘要

背景

多囊卵巢综合征（PCOS）患者的依从性问题尚未得到充分研究。患者报告称，治疗周期长和药物副作用是最常见的停药原因。为改善PCOS患者的有效管理，了解促进和抑制治疗依从性的因素至关重要。

目的

探讨PCOS患者治疗依从性的促进/抑制因素。

材料与方法

这是一项定性研究，采用目的抽样法选取确诊为PCOS的女性。通过对21至34岁女性进行20次深入的半结构化访谈收集数据。采用定性内容分析法对数据进行分析。

结果

确定了五个主题，描述了治疗依从性的不同类型的促进/抑制因素。抑制因素包括经济问题、患者相关因素、疾病相关因素和医疗服务提供者相关因素；而社会因素被发现既有促进作用也有抑制作用。

结论

研究结果表明，成功坚持PCOS治疗高度依赖于患者认识并适应经济、社会和医疗保健相关的抑制因素。临床医生和政策制定者认识到这些关键抑制因素对于改善治疗效果也至关重要。