Bossuyt Xavier
Laboratory Medicine, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Clin Chem. 2006 Feb;52(2):171-81. doi: 10.1373/clinchem.2005.058560. Epub 2005 Dec 8.
Inflammatory bowel disease (IBD) is an enduring disease involving mostly young people, with symptoms of bloody diarrhea and abdominal cramps. Several antibodies have been associated with IBD, the 2 most comprehensively studied being autoantibodies to neutrophils (atypical perinuclear anti-neutrophil cytoplasmic antibodies) and anti-Saccharomyces cerevisiae antibodies. This review focuses on the value of these antibodies for diagnosing IBD, differentiating Crohn disease from ulcerative colitis, indeterminate colitis, monitoring disease, defining clinical phenotypes, predicting response to therapy, and as subclinical markers. Pancreatic antibodies and newly identified anti-microbial antibodies (anti-outer membrane porin C, anti-I2, and anti-flagellin) are also reviewed.
炎症性肠病（IBD）是一种主要累及年轻人的慢性疾病，症状包括血性腹泻和腹部绞痛。几种抗体与IBD相关，其中研究最全面的两种是抗中性粒细胞自身抗体（非典型核周型抗中性粒细胞胞浆抗体）和抗酿酒酵母抗体。本综述重点关注这些抗体在诊断IBD、区分克罗恩病与溃疡性结肠炎、不确定性结肠炎、监测疾病、定义临床表型、预测治疗反应以及作为亚临床标志物方面的价值。还对胰腺抗体和新发现的抗微生物抗体（抗外膜孔蛋白C、抗I2和抗鞭毛蛋白）进行了综述。
