骨髓源性内皮细胞整合到肿瘤灌注血管中的证据。
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
作者信息
Duda Dan G, Cohen Kenneth S, Kozin Sergey V, Perentes Jean Y, Fukumura Dai, Scadden David T, Jain Rakesh K
机构信息
Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, COX 734, 100 Blossom St, Boston, MA 02114, USA.
出版信息
Blood. 2006 Apr 1;107(7):2774-6. doi: 10.1182/blood-2005-08-3210. Epub 2005 Dec 8.
Abstract
Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent to which bone marrow-derived cells incorporate as bona fide endothelial (nonhematopoietic) cells into perfused tumor vessels, or any new vessels formed postnatally (vasculogenesis), is unclear. To this end, we developed models to characterize local vessel-derived and bone marrow-derived endothelial cells (BMD-ECs). Then, we characterized the BMD-ECs based on a set of endothelial markers and morphology. Finally, we quantified their contribution to perfused blood vessels in tumors using transplanted as well as spontaneous primary and metastatic tumor models. We demonstrate that BMD-ECs incorporate in perfused tumor vessels, and that this contribution varies with organ site and mouse strain.
摘要
最近的研究表明，骨髓对肿瘤新生血管形成的细胞贡献非常复杂。在这种情况下，骨髓来源的细胞作为真正的内皮（非造血）细胞整合到灌注的肿瘤血管中，或出生后形成的任何新血管（血管生成）中的程度尚不清楚。为此，我们开发了模型来表征局部血管来源和骨髓来源的内皮细胞（BMD-ECs）。然后，我们根据一组内皮标志物和形态对BMD-ECs进行了表征。最后，我们使用移植以及自发的原发性和转移性肿瘤模型量化了它们对肿瘤灌注血管的贡献。我们证明BMD-ECs整合到灌注的肿瘤血管中，并且这种贡献因器官部位和小鼠品系而异。
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