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基质金属蛋白酶2与稳定的颈动脉粥样硬化病变相关,而基质金属蛋白酶8和9与易损的颈动脉粥样硬化病变相关:一项对人类动脉内膜切除术标本的研究表明不同的细胞外基质金属蛋白酶诱导剂糖基化形式发挥了作用。

Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms.

作者信息

Sluijter Joost P G, Pulskens Wilco P C, Schoneveld Arjan H, Velema Evelyn, Strijder Chaylendra F, Moll Frans, de Vries Jean-Paul, Verheijen Jan, Hanemaaijer Roeland, de Kleijn Dominique P V, Pasterkamp Gerard

机构信息

Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands.

出版信息

Stroke. 2006 Jan;37(1):235-9. doi: 10.1161/01.STR.0000196986.50059.e0. Epub 2005 Dec 8.

DOI:10.1161/01.STR.0000196986.50059.e0
PMID:16339461
Abstract

BACKGROUND AND PURPOSE

We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics.

METHODS

Carotid atherosclerotic plaques (n=150) were stained and analyzed for the presence of collagen, smooth muscle cell (SMC), and macrophages. Adjacent segments were used to isolate total protein to assess MMP-2 and MMP-9 activities and gelatin breakdown, MMP-8 activity, and EMMPRIN levels.

RESULTS

Macrophage-rich lesions revealed higher MMP-8 and MMP-9 activities, whereas SMC-rich lesions showed higher MMP-2 activity. The levels of less glycosylated EMMPRIN-45kD were higher in SMC-rich lesions and lower in macrophage-rich plaques. EMMPRIN-45kD was associated with MMP-2 levels, whereas EMMPRIN-58kD was related to MMP-9 levels.

CONCLUSIONS

MMP-2, MMP-8, and MMP-9 activities differed among carotid plaque phenotypes. Different EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity, which suggests that EMMPRIN glycosylation may play a role in MMP regulation and plaque destabilization.

摘要

背景与目的

我们研究了基质金属蛋白酶(MMP)2、8和9以及细胞外基质金属蛋白酶诱导剂(EMMPRIN)水平与颈动脉粥样硬化斑块特征的关系。

方法

对150个颈动脉粥样硬化斑块进行染色,并分析其中胶原蛋白、平滑肌细胞(SMC)和巨噬细胞的存在情况。使用相邻节段分离总蛋白,以评估MMP-2和MMP-9活性、明胶降解、MMP-8活性以及EMMPRIN水平。

结果

富含巨噬细胞的病变显示出较高的MMP-8和MMP-9活性,而富含SMC的病变则显示出较高的MMP-2活性。糖基化程度较低的EMMPRIN-45kD在富含SMC的病变中水平较高,在富含巨噬细胞的斑块中水平较低。EMMPRIN-45kD与MMP-2水平相关,而EMMPRIN-58kD与MMP-9水平相关。

结论

MMP-2、MMP-8和MMP-9活性在颈动脉斑块表型之间存在差异。不同的EMMPRIN糖基化形式与MMP-2或MMP-9活性相关,这表明EMMPRIN糖基化可能在MMP调节和斑块不稳定中发挥作用。

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