Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul 02841, Korea.
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea.
Int J Mol Sci. 2022 Sep 11;23(18):10546. doi: 10.3390/ijms231810546.
Matrix metalloproteinases (MMPs) are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are also involved in the inflammatory response by regulating the pro-inflammatory cytokines TNF-α and IL-1β. Dysregulation in the inflammatory response and changes in the extracellular matrix by MMPs are related to the development of various diseases including lung and cardiovascular diseases. Therefore, numerous studies have been conducted to understand the role of MMPs in disease pathogenesis. MMPs are involved in the pathogenesis of infectious diseases through a dysregulation of the activity and expression of MMPs. In this review, we discuss the role of MMPs in infectious diseases and inflammatory responses. Furthermore, we present the potential of MMPs as therapeutic targets in infectious diseases.
基质金属蛋白酶(MMPs)通过降解细胞外基质成分参与细胞外基质重塑,还通过调节促炎细胞因子 TNF-α和 IL-1β参与炎症反应。MMPs 引起的炎症反应失调和细胞外基质变化与包括肺部和心血管疾病在内的各种疾病的发展有关。因此,已经进行了许多研究来了解 MMPs 在疾病发病机制中的作用。MMPs 通过 MMPs 的活性和表达失调参与传染病的发病机制。在这篇综述中,我们讨论了 MMPs 在传染病和炎症反应中的作用。此外,我们还介绍了 MMPs 作为传染病治疗靶点的潜力。