Perlstein Todd S, Lee Richard T
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):250-6. doi: 10.1161/01.ATV.0000199268.27395.4f. Epub 2005 Dec 8.
Smoking causes up to 11% of total global cardiovascular deaths. Smoking has numerous effects that may promote atherosclerosis through vascular inflammation and oxidative stress, but the pathogenesis of smoking-related cardiovascular disease remains incompletely understood. The matrix metalloproteinases, a family of endopeptidases that can degrade extracellular matrix components in both physiological and pathophysiological states, play an important role in smoking-associated chronic obstructive pulmonary disease, the second leading cause of smoking attributable mortality. Emerging evidence indicates that the matrix metalloproteinases may also contribute to smoking-related vascular disease. Here we discuss the potential relationship between smoking, matrix metalloproteinases, and acceleration of vascular disease.
吸烟导致全球心血管疾病死亡总数的11%。吸烟有许多影响，可能通过血管炎症和氧化应激促进动脉粥样硬化，但吸烟相关心血管疾病的发病机制仍未完全了解。基质金属蛋白酶是一类内肽酶家族，在生理和病理生理状态下都能降解细胞外基质成分，在吸烟相关的慢性阻塞性肺疾病（吸烟导致死亡的第二大主要原因）中起重要作用。新出现的证据表明，基质金属蛋白酶也可能与吸烟相关的血管疾病有关。在此，我们讨论吸烟、基质金属蛋白酶与血管疾病加速之间的潜在关系。
