Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, Saint Catharines, ON, Canada.
Brock-Niagara Centre for Health and Well-Being, Brock University, Saint Catharines, ON, Canada.
Physiol Rep. 2021 Jun;9(11):e14920. doi: 10.14814/phy2.14920.
Central arterial stiffness is an independent predictor of cardiovascular disease. It is characterized by a marked reduction in the elastin-collagen ratio of the arterial wall extracellular matrix (ECM), and is largely the result of degradation of various ECM components. Matrix metalloproteinase-3 (MMP-3) may contribute to central arterial stiffness via its involvement in ECM homeostasis and remodeling. This study examined the association between serum MMP-3 concentrations and central arterial stiffness and potential interactions of MMP-3 and traditional cardiovascular risk factors in a population of healthy young adults. A total of 206 participants (n = 109 females) aged 19-25 years were included in the current study. Central arterial stiffness was measured non-invasively as carotid-femoral pulse wave velocity (cfPWV) (m/s). MMP-3 concentrations (ng/ml) were measured using ELISA techniques. Regression analyses were used to examine the association between cfPWV and MMP-3, adjusting for age, sex, smoking status, body mass index (BMI), instantaneous mean arterial pressure (MAP) and heart rate, and serum C-reactive protein. Interactions between MMP-3 with smoking, BMI, sex, and MAP were analyzed in subsequent regression models. MMP-3 was an independent predictor of cfPWV (β = 0.187, p = 0.007), and significant interactions between MMP-3 and regular smoking (β = 0.291, p = 0.022), and MMP-3 and BMI (β = 0.210, p = 0.013) were observed. Higher serum MMP-3 concentrations were associated with a faster cfPWV and thus, greater central arterial stiffness. Interactions between MMP-3 and smoking, and MMP-3 and BMI may, in part, drive the association between MMP-3 and central arterial stiffness.
中心动脉僵硬度是心血管疾病的独立预测因子。它的特征是动脉壁细胞外基质（ECM）中的弹性蛋白-胶原比例明显降低，主要是由于各种 ECM 成分的降解。基质金属蛋白酶-3（MMP-3）可能通过参与 ECM 稳态和重塑而导致中心动脉僵硬度。本研究旨在探讨健康年轻人群中血清 MMP-3 浓度与中心动脉僵硬度之间的关系，以及 MMP-3 与传统心血管危险因素之间的潜在相互作用。共纳入 206 名年龄在 19-25 岁的参与者（n=109 名女性）。中心动脉僵硬度通过颈股脉搏波速度（cfPWV）（m/s）进行无创测量。使用 ELISA 技术测量 MMP-3 浓度（ng/ml）。回归分析用于检查 cfPWV 与 MMP-3 之间的关系，调整年龄、性别、吸烟状况、体重指数（BMI）、瞬时平均动脉压（MAP）和心率以及血清 C 反应蛋白。在随后的回归模型中分析了 MMP-3 与吸烟、BMI、性别和 MAP 之间的相互作用。MMP-3 是 cfPWV 的独立预测因子（β=0.187，p=0.007），并且观察到 MMP-3 与有规律吸烟（β=0.291，p=0.022）和 MMP-3 与 BMI（β=0.210，p=0.013）之间存在显著的相互作用。较高的血清 MMP-3 浓度与较快的 cfPWV 相关，从而导致更大的中心动脉僵硬度。MMP-3 与吸烟和 MMP-3 与 BMI 之间的相互作用可能部分导致 MMP-3 与中心动脉僵硬度之间的关联。
