二次离子质谱分析表明，铍在慢性铍病肉芽肿中有所留存。
Secondary ion mass spectroscopy demonstrates retention of beryllium in chronic beryllium disease granulomas.
作者信息
Sawyer Richard T, Abraham Jerrold L, Daniloff Elaine, Newman Lee S
机构信息
Division of Environmental and Occupational Health Sciences, Robert Hollis Laboratory of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA.
出版信息
J Occup Environ Med. 2005 Dec;47(12):1218-26. doi: 10.1097/01.jom.0000184884.85325.36.
OBJECTIVE
We hypothesized that beryllium (Be) might persist in lung granulomas in patients with chronic beryllium disease (CBD).
METHODS
A total of 33 Be-exposed ceramics workers underwent transbronchial biopsy. They were classified based on histopathology and Be-lymphocyte proliferation test as CBD or other categories. Lung tissue sections were analyzed using secondary ion mass spectroscopy.
RESULTS
Be was detected in the lungs of all Be-exposed groups. Be levels were increased within the granulomas of patients with CBD compared with the Be levels outside granulomas. Notably, Be was detectable in the lungs of CBD patients who had ceased exposure to Be an average of 9 years previously.
CONCLUSIONS
Be was detected in the lungs of all Be-exposed subjects, with the highest levels of persistent Be inside CBD lung granulomas. Be antigen persistence may help explain the chronicity of this granulomatous disorder.
目的
我们推测铍（Be）可能会在慢性铍病（CBD）患者的肺部肉芽肿中持续存在。
方法
共有33名接触铍的陶瓷工人接受了经支气管活检。根据组织病理学和铍淋巴细胞增殖试验，将他们分为CBD组或其他类别。使用二次离子质谱分析法对肺组织切片进行分析。
结果
在所有接触铍的组中均检测到铍。与肉芽肿外的铍水平相比，CBD患者肉芽肿内的铍水平升高。值得注意的是，在平均9年前就已停止接触铍的CBD患者的肺部仍可检测到铍。
结论
在所有接触铍的受试者的肺部均检测到铍，CBD肺部肉芽肿内的铍持续水平最高。铍抗原的持续存在可能有助于解释这种肉芽肿性疾病的慢性病程。
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