Kubota Takao, Ushijima Yo, Okuyama Chio, Nishimura Tsunehiko
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.
Nucl Med Commun. 2006 Jan;27(1):37-44. doi: 10.1097/01.mnm.0000188220.99580.88.
To construct a region-of-interest (ROI) template for Z-score images of three-dimensional stereotactic surface projections (3-D SSP) and to assess whether the ROI template can be a useful tool for evaluation of brain perfusion abnormalities of neurological disorders.
We constructed the ROI template for Z-score images of 3-D SSP based on the standardized magnetic resonance imaging data of 10 healthy volunteers. We assigned a total of 26 ROIs to Z-score images and superimposed it on Z-score images constructed from the brain perfusion SPECT data of 15 patients with Alzheimer's disease and 10 patients with mild cognitive impairment (MCI) who developed Alzheimer's disease within the following 2 years. We then obtained the mean Z-scores of each ROI and examined them to determine whether the hypoperfusion typical of Alzheimer's disease had been demonstrated quantitatively. We also visually inspected the Z-score image of each patient in both groups to determine whether the areas with the highest Z-scores were demonstrated within the ROIs of regions typical of Alzheimer's disease.
In the patients with Alzheimer's disease, our ROI template quantitatively demonstrated hypoperfusion in regions typical of the disease and the Z-scores were very high. In the MCI patients, the mean Z-scores of the ROI in the posterior cingulated gyrus were the highest among all regions. Visual inspection of the Z-score images of each patient in both groups confirmed that the areas with the highest Z-scores were demonstrated within the ROIs in regions typical of Alzheimer's disease in all cases.
Use of 3-D SSP methods and our ROI template enables automated quantitative evaluation of brain function images over the entire brain surface. In addition, the ROI template may facilitate visual interpretation of functional images of individual patients with neurological disorders.
构建三维立体定向表面投影（3-D SSP）Z 评分图像的感兴趣区（ROI）模板，并评估该 ROI 模板是否可作为评估神经疾病脑灌注异常的有用工具。
我们基于 10 名健康志愿者的标准化磁共振成像数据构建了 3-D SSP Z 评分图像的 ROI 模板。我们为 Z 评分图像总共分配了 26 个 ROI，并将其叠加在由 15 例阿尔茨海默病患者和 10 例轻度认知障碍（MCI）患者的脑灌注 SPECT 数据构建的 Z 评分图像上，这些 MCI 患者在接下来的 2 年内发展为阿尔茨海默病。然后，我们获得每个 ROI 的平均 Z 评分，并对其进行检查以确定是否定量显示了阿尔茨海默病典型的灌注不足。我们还直观检查了两组中每位患者的 Z 评分图像，以确定 Z 评分最高的区域是否在阿尔茨海默病典型区域的 ROI 内显示。
在阿尔茨海默病患者中，我们的 ROI 模板定量显示了该疾病典型区域的灌注不足，且 Z 评分非常高。在 MCI 患者中，后扣带回 ROI 的平均 Z 评分在所有区域中最高。直观检查两组中每位患者的 Z 评分图像证实，在所有病例中，Z 评分最高的区域均在阿尔茨海默病典型区域的 ROI 内显示。
使用 3-D SSP 方法和我们的 ROI 模板能够对整个脑表面的脑功能图像进行自动定量评估。此外，ROI 模板可能有助于对患有神经疾病的个体患者的功能图像进行视觉解读。
