Reber H A, Karanjia N D, Alvarez C, Widdison A L, Leung F W, Ashley S W, Lutrin F J
Department of Surgery, Veteran's Administration Medical Center, Sepulveda, California.
Gastroenterology. 1992 Aug;103(2):652-9.
Pancreatic blood flow and its relationship to pancreatic interstitial pressure were investigated in a model of chronic pancreatitis in cats using a hydrogen gas-clearance technique with an intraductal electrode. The intraductal technique correlated well with blood flow measurements made using gamma-labeled microspheres (r = 0.88, P less than 0.001). In control cats, the basal blood flow of 69.1 +/- 9.5 mL.min-1.100 g-1 increased by 25% to 86.2 +/- 11 mL.min-1.100 g-1 with secretory stimulation (P less than 0.05). Interstitial pressure was -0.02 +/- 0.3 mm Hg and did not change significantly with stimulation. In cats with chronic pancreatitis, basal interstitial pressure was 1.8 +/- 0.5 mm Hg and basal blood flow 39.9 +/- 4 mL.min-1.100 g-1 (P less than 0.05). Stimulation of the chronic pancreatitis gland increased the pressure to 3.0 +/- 0.4 mm Hg (P less than 0.01) and reduced flow 15% to 34.2 +/- 4 mL.min-1.100 g-1 (P less than 0.05). Papaverine increased blood flow in control and chronic pancreatitis cats without altering tissue pressure, suggesting that despite the reduced basal blood flow, the ability to increase blood flow was preserved in chronic pancreatitis. The increased interstitial pressure associated with secretion appeared to limit the gland's normal hyperemic response in this model of chronic pancreatitis.
采用带有导管内电极的氢气清除技术，在猫慢性胰腺炎模型中研究了胰腺血流及其与胰腺间质压力的关系。导管内技术与使用γ标记微球进行的血流测量结果相关性良好（r = 0.88，P < 0.001）。在对照猫中，基础血流为69.1±9.5 mL·min⁻¹·100 g⁻¹，分泌刺激后增加25%至86.2±11 mL·min⁻¹·100 g⁻¹（P < 0.05）。间质压力为-0.02±0.3 mmHg，刺激后无显著变化。在慢性胰腺炎猫中，基础间质压力为1.8±0.5 mmHg，基础血流为39.9±4 mL·min⁻¹·100 g⁻¹（P < 0.05）。刺激慢性胰腺炎腺体可使压力升至3.0±0.4 mmHg（P < 0.01），血流减少15%至34.2±4 mL·min⁻¹·100 g⁻¹（P < 0.05）。罂粟碱可增加对照猫和慢性胰腺炎猫的血流，而不改变组织压力，这表明尽管基础血流减少，但慢性胰腺炎猫增加血流的能力仍得以保留。在该慢性胰腺炎模型中，与分泌相关的间质压力升高似乎限制了腺体正常的充血反应。
