乙醇对慢性胰腺炎猫胰腺间质pH值和血流的影响。

Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis.

作者信息

Toyama M T, Patel A G, Nguyen T, Ashley S W, Reber H A

机构信息

Department of Surgery, Sepulveda VA Medical Center, Los Angeles, California, USA.

出版信息

Ann Surg. 1997 Feb;225(2):223-8. doi: 10.1097/00000658-199702000-00011.

DOI:10.1097/00000658-199702000-00011

PMID:9065300

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1190652/

Abstract

OBJECTIVE

The objective of this study was to investigate the effects of ethanol on pancreatic blood flow and interstitial pH in chronic pancreatitis.

BACKGROUND

Ethanol is known to contribute to the development of both acute and chronic pancreatitis. However, it is unclear how ethanol precipitates episodes of acute pancreatic inflammation in the setting of chronic pancreatitis. In a model of chronic pancreatitis in cats, it is known that pancreatic blood flow is abnormally low and decreases further after ethanol ingestion. Because it is possible that this reduction in blood flow might be damaging to the pancreas, we investigated the effects of ethanol on pancreatic interstitial pH, an index of pancreatic ischemia.

METHODS

In normal cats and cats with obstructive chronic pancreatitis, pancreatic blood flow and interstitial pH were measured using the hydrogen gas clearance technique and pH microelectrode, respectively.

RESULTS

In normal cats, intragastric, but not intravenous, ethanol reduced both pancreatic blood flow by 62% (p < 0.05) and interstitial pH (7.38 +/- 0.03 to 7.20 +/- 0.03, p < 0.05). In cats with chronic pancreatitis in which basal pancreatic blood flow was already only 60% of normal flow, both intragastric and intravenous ethanol decreased both pancreatic blood flow (intragastric, 40% decrease, p < 0.05; intravenous, 34% decrease, p < 0.05) and interstitial pH (intragastric, 7.24 +/- 0.04 to 7.08 +/- 0.04, p < 0.05; intravenous 7.20 +/- 0.08 to 7.07 +/- 0.07, p < 0.05).

CONCLUSIONS

This profound decrease in pH, lasting up to 2 hours after ethanol exposure in the chronic pancreatitis animals, suggests the possibility of ischemic cellular damage to the pancreas. These findings may explain the pathogenesis of bouts of acute pancreatic inflammation after ethanol ingestion in the setting of chronic disease.

摘要

目的

本研究旨在探讨乙醇对慢性胰腺炎时胰腺血流及间质pH值的影响。

背景

已知乙醇会导致急性和慢性胰腺炎的发生。然而，目前尚不清楚在慢性胰腺炎的情况下乙醇是如何引发急性胰腺炎症发作的。在猫的慢性胰腺炎模型中，已知胰腺血流异常低，且在摄入乙醇后会进一步降低。由于这种血流减少可能对胰腺造成损害，我们研究了乙醇对胰腺间质pH值（胰腺缺血的一个指标）的影响。

方法

分别使用氢气清除技术和pH微电极测量正常猫和梗阻性慢性胰腺炎猫的胰腺血流和间质pH值。

结果

在正常猫中，经胃给予乙醇（而非静脉注射）可使胰腺血流减少62%（p<0.05），同时使间质pH值降低（从7.38±0.03降至7.20±0.03，p<0.05）。在基础胰腺血流仅为正常血流60%的慢性胰腺炎猫中，经胃和静脉给予乙醇均可降低胰腺血流（经胃给予降低40%，p<0.05；静脉注射降低34%，p<0.05）和间质pH值（经胃给予从7.24±0.04降至7.08±0.04，p<0.05；静脉注射从7.20±0.08降至7.07±0.07，p<0.05）。