Hyphantis T N, Bai M, Siafaka V, Georgiadis A N, Voulgari P V, Mavreas V, Drosos A A
Department of Psychiatry, Medical School, University of Ioannina, 45110 Ioannina, Greece.
Rheumatol Int. 2006 Jul;26(9):828-36. doi: 10.1007/s00296-005-0086-z. Epub 2005 Dec 9.
To investigate psychiatric manifestations, personality traits, and ego mechanisms of defense involved in early rheumatoid arthritis (RA).
Twenty-two unselected early RA outpatients with disease duration less than 1 year participated in the study. The majority of participants were females (72.7%), married (81.8%), aged 51.0+/-14.6 years. Thirty-four subjects matched for age, sex and educational level served as "healthy" controls. General Heath Questionnaire, Symptom Distress Checklist, Defense Style Questionnaire and Hostility and Direction of Hostility Questionnaire were used; disease activity was estimated by disease activity for 28-joint indices score.
Seven patients (31.8%) presented psychological distress scores indicative of possible psychiatric caseness, expressing obsessive-compulsive symptoms and depression, as compared to six (17.6%) of controls. Social dysfunction distress and somatization were prominent psychiatric manifestations in early RA group. Early RA patients tend to adopt a less adaptive defense style than controls. Although disease activity was not correlated to psychological distress, a significant association between disease activity and patients' defensive style was observed: as the disease is exacerbated, there was a shift from "non-adaptive" to "immature image distorting or borderline" defense style, suggesting a rather fragile underlying personality structure.
Psychological distress is a relatively common experience in early RA. Social dysfunction, along with the less adaptive defense style, which under the stress of the disease exacerbation turns to "borderline", underlines the importance of a careful assessment and consultation in early RA patients in order to face the distress shortly after diagnosis and highlights potential risk factors for future adaptation to exacerbations of the disease.
研究早期类风湿关节炎(RA)患者的精神症状、人格特质及防御机制。
选取22例病程小于1年的未经挑选的早期RA门诊患者参与研究。大多数参与者为女性(72.7%),已婚(81.8%),年龄51.0±14.6岁。34名年龄、性别和教育水平相匹配的受试者作为“健康”对照。使用一般健康问卷、症状困扰清单、防御方式问卷和敌意及敌意指向问卷;通过28个关节指数评分评估疾病活动度。
7例患者(31.8%)出现提示可能存在精神疾病的心理困扰评分,表现为强迫症状和抑郁,而对照组为6例(17.6%)。社会功能障碍困扰和躯体化是早期RA组突出的精神症状。早期RA患者比对照组更倾向于采用适应性较差的防御方式。虽然疾病活动度与心理困扰无关,但观察到疾病活动度与患者防御方式之间存在显著关联:随着疾病加重,防御方式从“非适应性”转变为“不成熟的形象扭曲或边缘型”,提示潜在的人格结构较为脆弱。
心理困扰在早期RA中是相对常见的经历。社会功能障碍,以及适应性较差的防御方式,在疾病加重的压力下转变为“边缘型”,强调了对早期RA患者进行仔细评估和咨询的重要性,以便在诊断后不久应对困扰,并突出了未来适应疾病加重的潜在风险因素。