Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Department of Neurosurgery, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Tremor Other Hyperkinet Mov (N Y). 2024 Sep 17;14:45. doi: 10.5334/tohm.935. eCollection 2024.
Deep brain stimulation of the subthalamic nucleus and globus pallidus internus is approved by the Food and Drug Administration for treating dystonia. Both targets have shown effectiveness in improving symptoms, but post-operative outcomes can vary significantly among patients. This variability has led researchers to explore alternative neuromodulation targets that might offer more consistent results. Emerging research has highlighted several promising new targets for DBS in dystonia. This review examines pre-clinical and clinical data on novel DBS targets for dystonia and explores non-invasive neuromodulation studies that shed light on the disease's underlying pathological circuitry.
脑深部电刺激丘脑底核和苍白球 internus 已获食品和药物管理局批准用于治疗肌张力障碍。这两个靶点都已显示出改善症状的有效性，但术后结果在患者之间可能有很大差异。这种可变性促使研究人员探索可能提供更一致结果的替代神经调节靶点。新兴研究强调了肌张力障碍的几个有前途的新 DBS 靶点。这篇综述检查了肌张力障碍的新 DBS 靶点的临床前和临床数据，并探讨了阐明疾病潜在病理回路的非侵入性神经调节研究。
