应激或感染人类免疫缺陷病毒（HIV）的淋巴细胞表面表达的热休克蛋白是抗体依赖性细胞毒性的靶点。
Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity.
作者信息
Di Cesare S, Poccia F, Mastino A, Colizzi V
机构信息
Department of Biology, University of Rome Tor Vergata, Italy.
出版信息
Immunology. 1992 Jun;76(2):341-3.
Abstract
The expression of heat-shock proteins (HSP) of the 72,000 MW family by Daudi and H9 lymphoma cells has been investigated by flow cytometry. It has been found that both heat-stressed and chronically human immunodeficiency virus (HIV)-infected lymphomas show an increased expression of heat-shock proteins (HSP). Moreover, murine monoclonal antibody (mAb) against 72,000 MW HSP was able to mediate antibody-dependent cellular cytotoxicity (ADCC) using peripheral blood lymphocytes (PBL) as effector cells. All target cells used in these experiments were efficiently lysed in the presence of anti-HSP antibody suggesting a role of membrane HSP in the elimination of stressed or infected cells.
摘要
通过流式细胞术研究了Daudi和H9淋巴瘤细胞中72,000分子量家族热休克蛋白（HSP）的表达。已发现热应激和慢性人类免疫缺陷病毒（HIV）感染的淋巴瘤均显示热休克蛋白（HSP）表达增加。此外，针对72,000分子量HSP的鼠单克隆抗体（mAb）能够以外周血淋巴细胞（PBL）作为效应细胞介导抗体依赖性细胞毒性（ADCC）。这些实验中使用的所有靶细胞在抗HSP抗体存在下均被有效裂解，提示膜HSP在清除应激或感染细胞中发挥作用。
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