1型人类免疫缺陷病毒感染不同临床阶段的自然细胞毒性和抗体依赖性细胞毒性。
Natural and antibody-dependent cytotoxicity in different clinical stages of human immunodeficiency virus type 1 infection.
作者信息
Ljunggren K, Karlson A, Fenyö E M, Jondal M
机构信息
Department of Immunology, Karolinska Institute, Stockholm, Sweden.
出版信息
Clin Exp Immunol. 1989 Feb;75(2):184-9.
Abstract
Peripheral blood mononuclear cells, PBMC, from 64 HIV-1-infected patients were tested for natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) functions against HIV-1-infected U937 clone 2 cells. The ADCC function was tested both with serum and effector cells from the same patient, with an HIV-1 antibody positive serum and with rabbit IgG antibodies against beta 2-microglobulin expressed on the virus-infected target cells. NK and ADCC functions were often found to be suppressed in HIV-1-infected individuals regardless of the severity of HIV-1 infection. The fact that impaired effector cell functions could be detected even in asymptomatic carriers, suggests that profound changes in cellular immunity may be present at an early stage of HIV-1 infection.
摘要
对64例HIV-1感染患者的外周血单个核细胞（PBMC）进行检测，以评估其针对HIV-1感染的U937克隆2细胞的自然杀伤（NK）功能和抗体依赖性细胞毒性（ADCC）功能。使用来自同一患者的血清和效应细胞、HIV-1抗体阳性血清以及针对病毒感染靶细胞上表达的β2-微球蛋白的兔IgG抗体来检测ADCC功能。无论HIV-1感染的严重程度如何，HIV-1感染个体的NK和ADCC功能常常被发现受到抑制。即使在无症状携带者中也能检测到效应细胞功能受损，这一事实表明在HIV-1感染的早期阶段可能就存在细胞免疫的深刻变化。
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Eur J Immunol. 1981 Jul;11(7):536-41. doi: 10.1002/eji.1830110703.
2
Dissociation of natural killer cell activity and antibody-dependent cell-mediated cytotoxicity in kidney allograft recipients receiving high-dose immunosuppressive therapy.接受大剂量免疫抑制治疗的肾移植受者中自然杀伤细胞活性与抗体依赖性细胞介导的细胞毒性的解离。
Transplantation. 1980 Mar;29(3):214-8. doi: 10.1097/00007890-198003000-00010.
3
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Science. 1984 Jul 6;225(4657):59-63. doi: 10.1126/science.6328660.
4
Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome.白细胞介素-2可增强获得性免疫缺陷综合征患者淋巴细胞中降低的自然杀伤细胞活性和巨细胞病毒特异性细胞毒性活性。
J Clin Invest. 1983 Jul;72(1):398-403. doi: 10.1172/jci110981.
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