Klemola Timo, Kalimo Kirsti, Poussa Tuija, Juntunen-Backman Kaisu, Korpela Riitta, Valovirta Erkka, Vanto Timo
Jorvi Hospital, Department of Pediatrics, Espoo, Finland.
Pediatr Allergy Immunol. 2005 Dec;16(8):641-6. doi: 10.1111/j.1399-3038.2005.00326.x.
Peanut allergy has been associated with the intake of soy milk or a soy formula. We studied the development of immunoglobulin E antibodies specific to soy and peanuts and of allergic reactions caused by peanuts, in children with confirmed cow's milk (CM) allergy fed either a soy formula or an extensively hydrolyzed formula (EHF). One hundred and seventy infants with documented CM allergy (CMA) were randomly assigned to receive either a soy formula or an EHF. The children were followed to the age of 4 yr. Peanut-specific immunoglobulin E was measured at the age of 4. A detailed history of the occurrence of allergic reactions caused by peanuts was recorded by the parents. Soy-specific immunoglobulin E antibodies were measured at the time of diagnosis and at the ages of 1, 2 and 4 yr. Immunoglobulin E antibodies to soy (> or =0.35 kU/l) were found in 22 of 70 children fed the soy formula, and in 14 of 70 of the children fed the EHF (p = 0.082). In an open challenge with soy at the age of 4, no immediate reactions were observed. One of 72 children from the soy group had a delayed reaction. immunoglobulin E antibodies to peanuts (> or =0.35 kU/l) were found in 21 of 70 children fed the soy formula and 17 of 69 infants fed the EHF (p = 0.717). The incidence of reported peanut allergy in the soy group was two of 72 (3%) and four of 76 (5%) in the EHF group (p = 0.68). Development of immunoglobulin E-associated allergy to soy and peanuts was rare in our study group of milk allergic children. The use of a soy formula during the first 2 yr of life did not increase the risk of development of peanut-specific immunoglobulin E antibodies or of clinical peanut allergy.
花生过敏与摄入豆奶或大豆配方奶粉有关。我们研究了确诊为牛奶（CM）过敏的儿童在喂养大豆配方奶粉或深度水解配方奶粉（EHF）后，针对大豆和花生的免疫球蛋白E抗体的产生以及花生引起的过敏反应。170名有记录的牛奶过敏（CMA）婴儿被随机分配接受大豆配方奶粉或EHF。对这些儿童进行随访至4岁。在4岁时测量花生特异性免疫球蛋白E。父母记录了由花生引起的过敏反应的详细发生史。在诊断时以及1、2和4岁时测量大豆特异性免疫球蛋白E抗体。在喂养大豆配方奶粉的70名儿童中有22名发现大豆免疫球蛋白E抗体（≥0.35 kU/l），在喂养EHF的70名儿童中有14名发现（p = 0.082）。在4岁时对大豆进行开放激发试验，未观察到即刻反应。大豆组的72名儿童中有1名出现延迟反应。在喂养大豆配方奶粉的70名儿童中有21名发现花生免疫球蛋白E抗体（≥0.35 kU/l），在喂养EHF的69名婴儿中有17名发现（p = 0.717）。大豆组报告的花生过敏发生率为72名中的2名（3%），EHF组为76名中的4名（5%）（p = 0.68）。在我们的牛奶过敏儿童研究组中，与免疫球蛋白E相关的大豆和花生过敏的发生很少见。在生命的头2年使用大豆配方奶粉不会增加产生花生特异性免疫球蛋白E抗体或临床花生过敏的风险。
