Feinstone S M, Kapikian A Z, Purcell R H, Alter H J, Holland P V
N Engl J Med. 1975 Apr 10;292(15):767-70. doi: 10.1056/NEJM197504102921502.
Twenty-two patients who had an episode of transfusion-associated hepatitis not positive for hepatitis B antigen were examined for development of antibody to heaptitis A and B antigens, cytomegalovirus and Epstein-Barr virus. Antibody response to the 27-nm virus-like hepatitis A antigen was measured by immune electron microscopy. In none of the 22 patients studied did serologic evidence of infection with hepatitis A virus develop during the study period. Nine of the 22 patients had antibody responses to cytomegalovirus, but it was difficult to relate these seroconversions to their hepatitis. In addition, all 22 patients had pre-existing antibody to the Epstein-Barr virus. It seems likely that at least a proportion of such antigen-negative transfusion-associated hepatitis is caused by other infectious agents, not yet identified.
对22例发生过输血相关性肝炎且乙型肝炎抗原检测呈阴性的患者，检测了甲型肝炎和乙型肝炎抗原、巨细胞病毒及EB病毒抗体的产生情况。通过免疫电镜检测对27纳米甲型肝炎病毒样抗原的抗体反应。在研究期间，所研究的22例患者中无一出现甲型肝炎病毒感染的血清学证据。22例患者中有9例对巨细胞病毒有抗体反应，但很难将这些血清转化与其肝炎联系起来。此外，所有22例患者先前均有EB病毒抗体。看来至少一部分此类抗原阴性的输血相关性肝炎是由尚未明确的其他感染因子引起的。
