Robaglia Christophe, Caranta Carole
Laboratoire de Génétique et Biophysique des Plantes, CEA-CNRS-Université Aix-Marseille II, Faculté des Sciences de Luminy, F-13009 Marseille, France.
Trends Plant Sci. 2006 Jan;11(1):40-5. doi: 10.1016/j.tplants.2005.11.004. Epub 2005 Dec 15.
Recessive resistance genes against plant viruses have been recognized for a long time but their molecular nature has only recently been linked to components of the eukaryotic translation initiation complex. Translation initiation factors, and particularly the eIF4E and eIF4G protein families, were found to be essential determinants in the outcome of RNA virus infections. Viruses affected by these genes belong mainly to potyviruses; natural viral resistance mechanisms as well as mutagenesis analysis in Arabidopsis all converged to identify the same set of translation initiation factors. Their role in plant resistance against RNA viruses remains to be elucidated. Although the interaction with the protein synthesis machinery is probably a key element for successful RNA virus infection, other possible mechanisms will also be discussed.
针对植物病毒的隐性抗性基因早已被认识到，但其分子本质直到最近才与真核生物翻译起始复合体的组分联系起来。翻译起始因子，尤其是eIF4E和eIF4G蛋白家族，被发现是RNA病毒感染结果的关键决定因素。受这些基因影响的病毒主要属于马铃薯Y病毒属；天然病毒抗性机制以及拟南芥中的诱变分析均汇聚于鉴定同一组翻译起始因子。它们在植物对RNA病毒的抗性中的作用仍有待阐明。尽管与蛋白质合成机制的相互作用可能是RNA病毒成功感染的关键因素，但其他可能的机制也将被讨论。
