Department of Chemistry, University of Maryland, College Park, Maryland 20742.
Appl Environ Microbiol. 1983 Aug;46(2):480-3. doi: 10.1128/aem.46.2.480-483.1983.
A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3'-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.
静止培养的根毛霉(ATCC 11145)将疣孢菌素 A 转化为 16-羟基疣孢菌素 A,而根毛霉将疣孢菌素 B 转化为 16-羟基疣孢菌素 B 和 3'-羟基疣孢菌素 A 的混合物。与疣孢菌素 A 和 B 相比,16-羟基衍生物在体内对 P388 小鼠白血病的活性明显增加。