一些12,13-环氧单端孢霉烯-9,10-烯的微生物和化学转化
Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes.
作者信息
Claridge C A, Schmitz H
出版信息
Appl Environ Microbiol. 1978 Jul;36(1):63-7. doi: 10.1128/aem.36.1.63-67.1978.
Abstract
Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests.
摘要
灰色链霉菌、总状毛霉的静止细胞以及醋酸钙不动杆菌的生长培养物，当与和12,13-环氧单端孢霉烯-9-烯-4β,15-二乙酰氧基-3α-醇（anguidine）相关的化合物混合时，会产生一系列部分水解或选择性酰化的衍生物。通过抗真菌和组织培养细胞毒性试验测定，这些衍生物在活性上表现出显著差异。
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