T-2毒素的体外代谢
In vitro metabolism of T-2 toxin.
作者信息
Ellison R A, Kotsonis F N
出版信息
Appl Microbiol. 1974 Feb;27(2):423-4. doi: 10.1128/am.27.2.423-424.1974.
Abstract
Incubation of T-2 toxin with the 9,000 x g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver. HT-2 toxin was not produced when human plasma was the incubating medium nor was it produced by treatment of T-2 toxin with simulated gastric juice. T-2 toxin was stable in gastric juice for at least 1 h.
摘要
将T-2毒素与人及牛肝脏匀浆的9000×g上清液一起孵育，结果转化为一种单一的、去乙酰化产物，鉴定为HT-2毒素。在人肝脏中代谢更快。当以人血浆作为孵育介质时不会产生HT-2毒素，用模拟胃液处理T-2毒素也不会产生HT-2毒素。T-2毒素在胃液中至少1小时内保持稳定。
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