Salive M E, Cornoni-Huntley J, Guralnik J M, Phillips C L, Wallace R B, Ostfeld A M, Cohen H J
Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892.
J Am Geriatr Soc. 1992 May;40(5):489-96. doi: 10.1111/j.1532-5415.1992.tb02017.x.
To determine the relationship of hemoglobin levels and anemia with age and health status in older adults.
Survey.
Community.
Hematologic tests were obtained from 3,946 adults aged greater than or equal to 71 years in three communities (East Boston, MA; Iowa and Washington counties, IA; and New Haven, CT).
Hemoglobin level was inversely associated with age, although this was more pronounced in men than in women. The proportion anemic was equal for men and women aged 71-74 years (8.6%) and increased differentially with age, reaching 41% and 21% for men and women aged greater than or equal to 90 years, respectively. Hemoglobin and anemia were independently associated with age, race, body-mass index, smoking, cancer, hospitalization, renal insufficiency, and hypoalbuminemia. The adjusted relative odds of anemia for a 5-year increase in age was 1.5 (95% confidence interval [CI] 1.3-1.8) for men and 1.2 (95% CI 1.1-1.4) for women.
Age is significantly associated with both hemoglobin levels and anemia, with a stronger effect in men compared with women, even after simultaneously adjusting for demographic characteristics and health status. The decline of hemoglobin and concomitant increased anemia with age is not necessarily a result of "normal aging" so the detection of anemia in an older person should prompt appropriate clinical attention.
确定老年人血红蛋白水平及贫血与年龄和健康状况之间的关系。
调查。
社区。
从三个社区（马萨诸塞州东波士顿；爱荷华州爱荷华县和华盛顿县；康涅狄格州纽黑文）的3946名年龄大于或等于71岁的成年人中获取血液学检测结果。
血红蛋白水平与年龄呈负相关，尽管男性比女性更明显。71 - 74岁男性和女性的贫血比例相同（8.6%），且随年龄增长差异增加，90岁及以上男性和女性的贫血比例分别达到41%和21%。血红蛋白和贫血与年龄、种族、体重指数、吸烟、癌症、住院、肾功能不全和低白蛋白血症独立相关。年龄每增加5岁，男性贫血的校正相对比值为1.5（95%置信区间[CI] 1.3 - 1.8），女性为1.2（95% CI 1.1 - 1.4）。
年龄与血红蛋白水平和贫血均显著相关，男性的影响比女性更强，即使在同时调整人口统计学特征和健康状况之后也是如此。血红蛋白水平随年龄下降以及贫血随之增加不一定是“正常衰老”的结果，因此老年人贫血的检测应引起适当的临床关注。
