Cooperative Institute for Research in Environmental Science and Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309-0215.
Appl Environ Microbiol. 1992 Apr;58(4):1385-7. doi: 10.1128/aem.58.4.1385-1387.1992.
4-Chlorobenzoate degradation in cell extracts of Acinetobacter sp. strain 4-CB1 occurs by initial synthesis of 4-chlorobenzoyl coenzyme A (4-chlorobenzoyl CoA) from 4-chlorobenzoate, CoA, and ATP. 4-Chlorobenzoyl CoA is dehalogenated to 4-hydroxybenzoyl CoA. Following the dehalogenation reaction, 4-hydroxybenzoyl CoA is hydrolyzed to 4-hydroxybenzoate and CoA. Possible roles for the CoA moiety in the dehalogenation reaction are discussed.
4-氯苯甲酸在不动杆菌菌株 4-CB1 的细胞提取物中的降解是通过 4-氯苯甲酸、辅酶 A 和 ATP 初始合成 4-氯苯甲酰辅酶 A(4-氯苯甲酰辅酶 A)来进行的。4-氯苯甲酰辅酶 A 脱卤生成 4-羟基苯甲酰辅酶 A。脱卤反应后,4-羟基苯甲酰辅酶 A 水解生成 4-羟基苯甲酸和辅酶 A。讨论了辅酶 A 部分在脱卤反应中的可能作用。