头孢菌素C的生物合成：I. 影响发酵的因素
Biosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.
作者信息
Ott J L, Godzeski C W, Pavey D, Farran J D, Horton D R
机构信息
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
出版信息
Appl Microbiol. 1962 Nov;10(6):515-23. doi: 10.1128/am.10.6.515-523.1962.
Abstract
A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I. 49,137). dl-Methionine increased the yield of both antibiotics, with more effect on cephalosporin N. l-Cystine had a greater enhancing effect on formation of cephalosporin C than on formation of cephalosporin N in synthetic media; serine increased yields of cephalosporin C under certain conditions. Disaccharides or polysaccharides appeared to be the best source for carbohydrates. No evidence was found for precursor action such as is found in penicillin fermentations. The ability of resting cells to produce antibiotic was demonstrated.
摘要
已经开发出一系列复杂的合成培养基，适用于头孢霉突变菌株（C.M.I. 49,137）生产头孢菌素C和头孢菌素N。dl-蛋氨酸提高了两种抗生素的产量，对头孢菌素N的影响更大。在合成培养基中，l-胱氨酸对头孢菌素C形成的促进作用比对头孢菌素N形成的促进作用更大；在某些条件下，丝氨酸提高了头孢菌素C的产量。二糖或多糖似乎是碳水化合物的最佳来源。未发现有青霉素发酵中存在的前体作用的证据。证实了静息细胞产生抗生素的能力。
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本文引用的文献
1
Penicillin: X. The Effect of Phenylacetic Acid on Penicillin Production.
J Bacteriol. 1947 Mar;53(3):329-41.
2
Assay of Streptomycin by the Paper-Disc Plate Method.
J Bacteriol. 1945 Dec;50(6):701-9.
3
Antibiotic production by a species of Cephalosporium.
J Gen Microbiol. 1952 Feb;6(1-2):47-59. doi: 10.1099/00221287-6-1-2-47.
4
Isolation of antibiotics from a species of Cephalosporium; cephalosporins P1, P2, P3, P4, and P5.
Biochem J. 1951 Dec;50(2):168-74. doi: 10.1042/bj0500168.
5
Synnematin, and antibiotic produced by Tilachlidium.
Proc Soc Exp Biol Med. 1951 Feb;76(2):307-11. doi: 10.3181/00379727-76-18473.
6
Further degradation products of cephalosporin C. Isolation and synthesis of 2-(4-amino-4-carboxybutyl)thiazole-4-carboxylic acid.
Biochem J. 1960 May;75(2):216-23. doi: 10.1042/bj0750216.
7
Cephalosporin C, a new antibiotic containing sulphur and D-alpha-aminoadipic acid.
Nature. 1955 Mar 26;175(4456):548. doi: 10.1038/175548a0.
8
The cephalosporin C nucleus (7-aminocephalosporanic acid) and some of its derivatives.
Biochem J. 1961 May;79(2):408-16. doi: 10.1042/bj0790408.
9
The structure of cephalesporin C.
Biochem J. 1961 May;79(2):377-93. doi: 10.1042/bj0790377.
10
Production, purification, and characterization of synnematin.
J Bacteriol. 1959 Feb;77(2):217-26. doi: 10.1128/jb.77.2.217-226.1959.
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