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相似文献

1
Biosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.头孢菌素C的生物合成：I. 影响发酵的因素
Appl Microbiol. 1962 Nov;10(6):515-23. doi: 10.1128/am.10.6.515-523.1962.
2
Biosynthesis of penicillin N and cephalosporin C. Antibiotic production and other features of the metabolism of Cephalosporium sp.青霉素N和头孢菌素C的生物合成。头孢霉属的抗生素生产及代谢的其他特征
Biochem J. 1967 Jun;103(3):877-90. doi: 10.1042/bj1030877.
3
Effect of methionine on cephalosporin C and penicillin N production by a mutant of Cephalosporium acremonium.蛋氨酸对顶头孢霉突变体生产头孢菌素C和青霉素N的影响。
J Antibiot (Tokyo). 1975 Nov;28(11):881-8. doi: 10.7164/antibiotics.28.881.
4
Sulfur metabolism of a mutant of Cephalosporium acremonium with enhanced potential to utilize sulfate for cephalosporin C production.顶头孢霉一个突变体的硫代谢，该突变体利用硫酸盐生产头孢菌素C的潜力增强。
J Antibiot (Tokyo). 1977 Mar;30(3):226-33. doi: 10.7164/antibiotics.30.226.
5
Carbon catabolite regulation of the conversion of penicillin N into cephalosporin C.青霉素N转化为头孢菌素C的碳分解代谢调控
J Antibiot (Tokyo). 1983 Jun;36(6):700-8. doi: 10.7164/antibiotics.36.700.
6
The role of valine in the biosynthesis of penicillin N and cephalosporin C by a Cephalosporium sp.缬氨酸在头孢霉属某菌株合成青霉素N和头孢菌素C中的作用
Biochem J. 1967 Jun;103(3):902-12. doi: 10.1042/bj1030902.
7
Influence of medium composition on the cephalosporin C production with a highly productive strain Cephalosporium acremonium.培养基成分对高产菌株顶头孢霉生产头孢菌素C的影响。
J Biotechnol. 1992 May;23(3):315-29. doi: 10.1016/0168-1656(92)90078-n.
8
Defining an optimal carbon source/methionine feed strategy for growth and cephalosporin C formation by Cephalosporium acremonium.确定顶头孢霉生长及头孢菌素C形成的最佳碳源/蛋氨酸补料策略。
Biotechnol Prog. 1990 Sep-Oct;6(5):333-40. doi: 10.1021/bp00005a004.
9
Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media.蛋氨酸、正亮氨酸和赖氨酸衍生物对化学限定培养基中头孢菌素C形成的影响。
J Bacteriol. 1963 Feb;85(2):339-44. doi: 10.1128/jb.85.2.339-344.1963.
10
Production of cephalosporin C by single and double sulfur auxotrophic mutants of Cephalosporium acremonium.顶头孢霉单硫营养缺陷型和双硫营养缺陷型突变体生产头孢菌素C
Antimicrob Agents Chemother. 1975 Jul;8(1):5-10. doi: 10.1128/AAC.8.1.5.

引用本文的文献

1
Effect of Methionine and Sulfate on the Metabolism of Cephalosporium acremonium.蛋氨酸和硫酸盐对顶头孢霉代谢的影响。
Appl Microbiol. 1968 Dec;16(12):1913-8. doi: 10.1128/am.16.12.1913-1918.1968.
2
Regulation of cephalosporin synthesis in Cephalosporium acremonium by phosphate and glucose.磷酸盐和葡萄糖对顶头孢霉中头孢菌素合成的调控
Arch Microbiol. 1980 Nov;128(1):78-83. doi: 10.1007/BF00422309.
3
Biosynthesis of penicillin N and cephalosporin C. Antibiotic production and other features of the metabolism of Cephalosporium sp.青霉素N和头孢菌素C的生物合成。头孢霉属的抗生素生产及代谢的其他特征
Biochem J. 1967 Jun;103(3):877-90. doi: 10.1042/bj1030877.
4
Role of methionine in cephalosporin synthesis.蛋氨酸在头孢菌素合成中的作用。
Appl Microbiol. 1966 Sep;14(5):746-53. doi: 10.1128/am.14.5.746-753.1966.
5
Synthesis of cephalosporin C from sulfate by mutants of Cephalosporium acremonium.顶头孢霉突变体从硫酸盐合成头孢菌素C。
Antimicrob Agents Chemother. 1973 Oct;4(4):474-8. doi: 10.1128/AAC.4.4.474.
6
Production of cephalosporin C by Paecilomyces persicinus P-10.嗜热栖热放线菌P-10生产头孢菌素C。
Antimicrob Agents Chemother. 1974 Oct;6(4):447-51. doi: 10.1128/AAC.6.4.447.
7
Interference by methionine on valine uptake in Acremonium chrysogenum.蛋氨酸对产黄顶孢霉中缬氨酸摄取的干扰。
Antimicrob Agents Chemother. 1987 Feb;31(2):357-9. doi: 10.1128/AAC.31.2.357.
8
Production of cephalosporin C by single and double sulfur auxotrophic mutants of Cephalosporium acremonium.顶头孢霉单硫营养缺陷型和双硫营养缺陷型突变体生产头孢菌素C
Antimicrob Agents Chemother. 1975 Jul;8(1):5-10. doi: 10.1128/AAC.8.1.5.
9
A chemically defined medium for cephalosporin C production by Paecilomyces persicinus.一种用于产黄青霉生产头孢菌素C的化学成分确定的培养基。
Antonie Van Leeuwenhoek. 1976;42(3):299-308. doi: 10.1007/BF00394127.

本文引用的文献

1
Penicillin: X. The Effect of Phenylacetic Acid on Penicillin Production.青霉素：十、苯乙酸对青霉素生产的影响
J Bacteriol. 1947 Mar;53(3):329-41.
2
Assay of Streptomycin by the Paper-Disc Plate Method.纸片平板法测定链霉素
J Bacteriol. 1945 Dec;50(6):701-9.
3
Antibiotic production by a species of Cephalosporium.一种头孢霉属真菌的抗生素生产。
J Gen Microbiol. 1952 Feb;6(1-2):47-59. doi: 10.1099/00221287-6-1-2-47.
4
Isolation of antibiotics from a species of Cephalosporium; cephalosporins P1, P2, P3, P4, and P5.从一种头孢霉中分离抗生素；头孢菌素P1、P2、P3、P4和P5。
Biochem J. 1951 Dec;50(2):168-74. doi: 10.1042/bj0500168.
5
Synnematin, and antibiotic produced by Tilachlidium.
Proc Soc Exp Biol Med. 1951 Feb;76(2):307-11. doi: 10.3181/00379727-76-18473.
6
Further degradation products of cephalosporin C. Isolation and synthesis of 2-(4-amino-4-carboxybutyl)thiazole-4-carboxylic acid.头孢菌素C的进一步降解产物。2-(4-氨基-4-羧基丁基)噻唑-4-羧酸的分离与合成。
Biochem J. 1960 May;75(2):216-23. doi: 10.1042/bj0750216.
7
Cephalosporin C, a new antibiotic containing sulphur and D-alpha-aminoadipic acid.头孢菌素C，一种含硫和D-α-氨基己二酸的新型抗生素。
Nature. 1955 Mar 26;175(4456):548. doi: 10.1038/175548a0.
8
The cephalosporin C nucleus (7-aminocephalosporanic acid) and some of its derivatives.头孢菌素C核心（7-氨基头孢烷酸）及其一些衍生物。
Biochem J. 1961 May;79(2):408-16. doi: 10.1042/bj0790408.
9
The structure of cephalesporin C.头孢菌素C的结构。
Biochem J. 1961 May;79(2):377-93. doi: 10.1042/bj0790377.
10
Production, purification, and characterization of synnematin.束丝放线菌素的生产、纯化及特性分析
J Bacteriol. 1959 Feb;77(2):217-26. doi: 10.1128/jb.77.2.217-226.1959.

头孢菌素C的生物合成：I. 影响发酵的因素

Biosynthesis of Cephalosporin C: I. Factors Affecting the Fermentation.

作者信息

Ott J L, Godzeski C W, Pavey D, Farran J D, Horton D R

机构信息

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.

出版信息

Appl Microbiol. 1962 Nov;10(6):515-23. doi: 10.1128/am.10.6.515-523.1962.

DOI:10.1128/am.10.6.515-523.1962
PMID:16349624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1057906/
Abstract

A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I. 49,137). dl-Methionine increased the yield of both antibiotics, with more effect on cephalosporin N. l-Cystine had a greater enhancing effect on formation of cephalosporin C than on formation of cephalosporin N in synthetic media; serine increased yields of cephalosporin C under certain conditions. Disaccharides or polysaccharides appeared to be the best source for carbohydrates. No evidence was found for precursor action such as is found in penicillin fermentations. The ability of resting cells to produce antibiotic was demonstrated.

摘要

已经开发出一系列复杂的合成培养基，适用于头孢霉突变菌株（C.M.I. 49,137）生产头孢菌素C和头孢菌素N。dl-蛋氨酸提高了两种抗生素的产量，对头孢菌素N的影响更大。在合成培养基中，l-胱氨酸对头孢菌素C形成的促进作用比对头孢菌素N形成的促进作用更大；在某些条件下，丝氨酸提高了头孢菌素C的产量。二糖或多糖似乎是碳水化合物的最佳来源。未发现有青霉素发酵中存在的前体作用的证据。证实了静息细胞产生抗生素的能力。