Alonso M J, Luengo J M
Antimicrob Agents Chemother. 1987 Feb;31(2):357-9. doi: 10.1128/AAC.31.2.357.
The incorporation of L-[U-14C]valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV), a direct biosynthetic precursor of penicillins and cephalosporins, was studied. When DL-methionine was added to Acremonium chrysogenum culture broths, no labeled ACV was found, while a large amount of radioactive ACV was detected when methionine was not present. DL-Norleucine, a nonsulfur analog of methionine, also inhibited the synthesis of radioactive ACV to some degree. This effect was due to the inhibition of valine transport by methionine and norleucine.
研究了将L-[U-¹⁴C]缬氨酸掺入青霉素和头孢菌素的直接生物合成前体δ-(L-α-氨基己二酰基)-L-半胱氨酰-D-缬氨酸（ACV）的情况。当向产黄青霉培养液中添加DL-甲硫氨酸时，未发现标记的ACV，而在不存在甲硫氨酸时检测到大量放射性ACV。甲硫氨酸的非硫类似物DL-正亮氨酸也在一定程度上抑制了放射性ACV的合成。这种作用是由于甲硫氨酸和正亮氨酸对缬氨酸转运的抑制。
