Kogiso M, Tanouchi Y, Miki S, Mimura Y
Department of Ophthalmology, Tokushima University School of Medicine, Japan.
Jpn J Ophthalmol. 1992;36(1):37-43.
The lymphocyte subunits and subsets of 12 patients with Vogt-Koyanagi-Harada disease (VKH disease) were characterized using two-color flow cytometry techniques, both in cerebrospinal fluid (CSF) and in peripheral blood (PB). Soluble interleukin-2 receptor (sIL-2R) levels and interleukin-6 (IL-6) levels were also measured. The percentage of T cells was significantly higher in CSF than in PB (P less than 0.01), but the percentage of B cells was decreased in CSF (P less than 0.05). As for T-cell subsets, the percentage of helper T cells was especially high in CSF (P less than 0.01). Also, the ratio of helper T cells/suppressor T cells was significantly larger in CSF than in PB. These data suggest that helper T cells play an important role in the early stages of VKH disease. sIL-2R and IL-6 levels were not elevated in CSF of patients with VKH disease. The level of sIL-2R in serum also was not elevated.
采用双色流式细胞术对12例原田小柳-原田病（VKH病）患者的淋巴细胞亚群进行了检测，样本包括脑脊液（CSF）和外周血（PB）。同时检测了可溶性白细胞介素-2受体（sIL-2R）水平和白细胞介素-6（IL-6）水平。脑脊液中T细胞百分比显著高于外周血（P<0.01），但脑脊液中B细胞百分比降低（P<0.05）。至于T细胞亚群，脑脊液中辅助性T细胞百分比尤其高（P<0.01）。此外，脑脊液中辅助性T细胞/抑制性T细胞的比例显著高于外周血。这些数据表明，辅助性T细胞在VKH病的早期阶段起重要作用。VKH病患者脑脊液中的sIL-2R和IL-6水平未升高。血清中的sIL-2R水平也未升高。
