克雅氏病一例中周期性同步放电时单光子发射计算机断层扫描的系列变化

Serial changes of SPECT in periodic synchronous discharges in a case with Creutzfeldt-Jakob disease.

作者信息

Kan R, Takahashi Y, Sato K, Watabe M, Tago H, Yashima Y, Kumashiro H

机构信息

Department of Neuropsychiatry, Fukushima Medical College, Japan.

出版信息

Jpn J Psychiatry Neurol. 1992 Mar;46(1):175-9. doi: 10.1111/j.1440-1819.1992.tb00831.x.

DOI:10.1111/j.1440-1819.1992.tb00831.x

PMID:1635307

Abstract

We conducted serial EEG and SPECT studies on one female with Creutzfeldt-Jakob disease (CJD). In an analysis of EEG, a periodic synchronous discharge (PSD) was observed in the middle of the third stage (terminal stage) of Bernoulli's classification. The frequency of PSD was the highest at the beginning of the third stage, followed by a gradual decrease and disappeared at the end of the third stage. In the middle of the third stage, SPECT disclosed blood flow differences between the cerebrum and other regions (the cerebellum and the brainstem), while no such difference was observed by SPECT at the end of the third stage. It was suggested that the appearance of PSD requires the presence of a pathological change in the cerebrum precedent to other regions.

摘要

我们对一名克雅氏病（CJD）女性患者进行了系列脑电图（EEG）和单光子发射计算机断层扫描（SPECT）研究。在脑电图分析中，在伯努利分类法第三阶段（终末期）中期观察到周期性同步放电（PSD）。PSD频率在第三阶段开始时最高，随后逐渐下降并在第三阶段结束时消失。在第三阶段中期，SPECT显示大脑与其他区域（小脑和脑干）之间存在血流差异，而在第三阶段结束时SPECT未观察到此类差异。提示PSD的出现需要大脑先于其他区域发生病理改变。