Jibiki I, Fukushima T, Kobayashi K, Kurokawa K, Yamaguchi N, Matsuda H, Hisada K
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Neuropsychobiology. 1994;29(3):117-9. doi: 10.1159/000119073.
Serial changes in brain imaging of regional cerebral blood flow with single photon emission computed tomography (SPECT) using N-isopropyl-(iodine-123) p-iodoamphetamine (123I-IMP) were observed in a patient with probable Heidenhain type of Creutzfeldt-Jakob disease, which was characterized by the initial onset of visual symptoms. Corresponding to the visual signs and periodic synchronous discharges localized in the bilateral parietal and occipital regions on EEG, focal hypoperfusion images in the occipital lobes were detected on the SPECT scan before brain X-ray computed tomography and magnetic resonance imaging showed any abnormalities. These results suggest that SPECT brain imaging is useful in the early detection of site-specific abnormalities in Creutzfeldt-Jakob disease.
在一名可能为Heidenhain型克雅氏病的患者中，观察到使用N-异丙基-（碘-123）对碘安非他明（123I-IMP）的单光子发射计算机断层扫描（SPECT）对局部脑血流进行的脑成像系列变化，该患者以视觉症状首发为特征。与脑电图上双侧顶叶和枕叶出现的视觉体征及周期性同步放电相对应，在脑部X线计算机断层扫描和磁共振成像显示任何异常之前，SPECT扫描检测到枕叶的局灶性灌注不足图像。这些结果表明，SPECT脑成像有助于克雅氏病部位特异性异常的早期检测。
