通过机械化学筛选结晶盐。
Screening for crystalline salts via mechanochemistry.
作者信息
Trask Andrew V, Haynes Delia A, Motherwell W D Samuel, Jones William
机构信息
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
出版信息
Chem Commun (Camb). 2006 Jan 7(1):51-3. doi: 10.1039/b512626f. Epub 2005 Nov 21.
DOI:10.1039/b512626f
PMID:16353089
Abstract
Neat grinding and solvent-drop grinding methods are found to be effective screening tools for indicating the potential for crystalline salt formation involving a given acid-base pair, as demonstrated with two model pharmaceuticals.
摘要
如两种模型药物所示，纯研磨法和溶剂滴研磨法被发现是有效的筛选工具，可用于表明涉及特定酸碱对形成结晶盐的可能性。
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