壳聚糖与水解明胶喷雾干燥混合物作为片剂黏合剂的研究：技术说明
Studies on spray-dried mixtures of chitosan and hydrolyzed gelatin as tablet binder: a technical note.
作者信息
Kokil Suruchi, Patil Pradeep, Mahadik Kakasaheb, Paradkar Anant
机构信息
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune 411 038 India.
出版信息
AAPS PharmSciTech. 2005 Oct 22;6(3):E437-43. doi: 10.1208/pt060354.
Abstract
The results of this investigation showed that spray drying of CH and HG resulted in free-flowing powder, which exhibited improved compressibility and compactibility, thereby suggesting the potential of such spray-dried mixtures of CH and HG as binder in tablets. Optimization of CH:HG ratio needs to be undertaken on a case basis, depending on the presence of other excipients in the formulation.
摘要
本次研究结果表明，对壳聚糖（CH）和羟丙基瓜尔胶（HG）进行喷雾干燥可得到流动性良好的粉末，其可压性和成型性得到改善，这表明CH和HG的喷雾干燥混合物作为片剂粘合剂具有潜力。CH:HG比例的优化需要根据具体情况进行，这取决于制剂中其他辅料的存在情况。
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